Literature summary for 3.1.1.1 extracted from

Igawa, Y.; Fujiwara, S.; Ohura, K.; Hirokawa, T.; Nishizawa, Y.; Uehara, S.; Uno, Y.; Imai, T.
Differences in intestinal hydrolytic activities between cynomolgus monkeys and humans evaluation of substrate specificities using recombinant carboxylesterase 2 isozymes (2016), Mol. Pharm., 13, 3176-3186 .

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism
additional information	-	additional information	kinetics	Homo sapiens
additional information	-	additional information	kinetics	Macaca fascicularis
0.0024	-	(R)-propranolyl 3-methylbutanoate	enzyme hCE2, pH and temperature not specified in the publication	Homo sapiens
0.004	-	(S)-propranolyl 3-methylbutanoate	enzyme hCE2, pH and temperature not specified in the publication	Homo sapiens
0.0045	-	(S)-propranolyl 2-methylbutanoate	enzyme mfCES2v3, pH and temperature not specified in the publication	Macaca fascicularis
0.0066	-	(S)-propranolyl n-valerate	enzyme mfCES2v3, pH and temperature not specified in the publication	Macaca fascicularis
0.0072	-	(R)-propranolyl 3-methylbutanoate	enzyme mfCES2v3, pH and temperature not specified in the publication	Macaca fascicularis
0.009	-	(S)-propranolyl 3-methylbutanoate	enzyme mfCES2v3, pH and temperature not specified in the publication	Macaca fascicularis
0.0106	-	(R)-propranolyl n-valerate	enzyme mfCES2v3, pH and temperature not specified in the publication	Macaca fascicularis
0.012	-	(R)-propranolyl n-valerate	enzyme hCE2, pH and temperature not specified in the publication	Homo sapiens
0.0125	-	(R)-propranolyl 2-methylbutanoate	enzyme hCE2, pH and temperature not specified in the publication	Homo sapiens
0.0132	-	(R)-propranolyl 2-methylbutanoate	enzyme mfCES2v3, pH and temperature not specified in the publication	Macaca fascicularis
0.0149	-	(S)-propranolyl 2-methylbutanoate	enzyme hCE2, pH and temperature not specified in the publication	Homo sapiens
0.0178	-	(S)-propranolyl n-valerate	enzyme hCE2, pH and temperature not specified in the publication	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
microsome	-	Homo sapiens	-	-
microsome	-	Macaca fascicularis	-	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O00748	-	-
Macaca fascicularis	A0A2K5V282	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
intestine	-	Homo sapiens	-
intestine	-	Macaca fascicularis	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.
(R)-propranolyl 2-methyl-n-valerate + H2O	-	Homo sapiens	(R)-propranolol + 2-methylpentanoate	-	?
(R)-propranolyl 2-methyl-n-valerate + H2O	-	Macaca fascicularis	(R)-propranolol + 2-methylpentanoate	-	?
(R)-propranolyl 2-methylbutanoate + H2O	-	Homo sapiens	(R)-propranolol + 2-methylbutanoate	-	?
(R)-propranolyl 2-methylbutanoate + H2O	-	Macaca fascicularis	(R)-propranolol + 2-methylbutanoate	-	?
(R)-propranolyl 3-methylbutanoate + H2O	-	Homo sapiens	(R)-propranolol + 3-methylbutanoate	-	?
(R)-propranolyl 3-methylbutanoate + H2O	-	Macaca fascicularis	(R)-propranolol + 3-methylbutanoate	-	?
(R)-propranolyl 3-methylpentanoate + H2O	-	Homo sapiens	(R)-propranolol + 3-methylpentanoate	-	?
(R)-propranolyl 3-methylpentanoate + H2O	-	Macaca fascicularis	(R)-propranolol + 3-methylpentanoate	-	?
(R)-propranolyl hexanoate + H2O	-	Homo sapiens	(R)-propranolol + hexanoate	-	?
(R)-propranolyl hexanoate + H2O	-	Macaca fascicularis	(R)-propranolol + hexanoate	-	?
(R)-propranolyl n-valerate + H2O	-	Homo sapiens	(R)-propranolol + pentanoate	-	?
(R)-propranolyl n-valerate + H2O	-	Macaca fascicularis	(R)-propranolol + pentanoate	-	?
(S)-propranolol 3-methylpentanoate + H2O	-	Homo sapiens	(S)-propranolol + 3-methylpentanoate	-	?
(S)-propranolol 3-methylpentanoate + H2O	-	Macaca fascicularis	(S)-propranolol + 3-methylpentanoate	-	?
(S)-propranolyl 2-methylbutanoate + H2O	-	Homo sapiens	(S)-propranolol + 2-methylbutanoate	-	?
(S)-propranolyl 2-methylbutanoate + H2O	-	Macaca fascicularis	(S)-propranolol + 2-methylbutanoate	-	?
(S)-propranolyl 2-methylpentanoate + H2O	-	Homo sapiens	(S)-propranolol + 2-methylpentanoate	-	?
(S)-propranolyl 2-methylpentanoate + H2O	-	Macaca fascicularis	(S)-propranolol + 2-methylpentanoate	-	?
(S)-propranolyl 3-methylbutanoate + H2O	-	Homo sapiens	(S)-propranolol + 3-methylbutanoate	-	?
(S)-propranolyl 3-methylbutanoate + H2O	-	Macaca fascicularis	(S)-propranolol + 3-methylbutanoate	-	?
(S)-propranolyl hexanoate + H2O	-	Homo sapiens	(S)-propranolol + hexanoate	-	?
(S)-propranolyl hexanoate + H2O	-	Macaca fascicularis	(S)-propranolol + hexanoate	-	?
(S)-propranolyl n-valerate + H2O	-	Homo sapiens	(S)-propranolol + pentanoate	-	?
(S)-propranolyl n-valerate + H2O	-	Macaca fascicularis	(S)-propranolol + pentanoate	-	?
butyl 4-aminobenzoate + H2O	-	Homo sapiens	4-aminobenzoate + butanol	-	?
butyl 4-aminobenzoate + H2O	-	Macaca fascicularis	4-aminobenzoate + butanol	-	?
ethyl 4-aminobenzoate + H2O	-	Homo sapiens	4-aminobenzoate + ethanol	-	?
ethyl 4-aminobenzoate + H2O	-	Macaca fascicularis	4-aminobenzoate + ethanol	-	?
methyl 4-aminobenzoate + H2O	-	Homo sapiens	4-aminobenzoate + methanol	-	?
methyl 4-aminobenzoate + H2O	-	Macaca fascicularis	4-aminobenzoate + methanol	-	?
additional information	enzyme hCE2 prefers the (S)-isomer configuration. Docking simulations of CES2 and propranolol derivatives. Substrate specifcity, overview	Homo sapiens	?	-	?
additional information	enzyme hCE2 prefers the (S)-isomer configuration. Docking simulations of CES2 and propranolol derivatives. Substrate specifcity, overview	Macaca fascicularis	?	-	?
propyl 4-aminobenzoate + H2O	-	Homo sapiens	4-aminobenzoate + propanol	-	?
propyl 4-aminobenzoate + H2O	-	Macaca fascicularis	4-aminobenzoate + propanol	-	?

Synonyms

Synonyms	Comment	Organism
carboxylesterase 2	-	Homo sapiens
carboxylesterase 2	-	Macaca fascicularis
HCE2	-	Homo sapiens
mfCES2v3	-	Macaca fascicularis