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Literature summary for 3.1.1.1 extracted from
- Purification of a chymotrypsin-like enzyme present on adult Schistosoma mansoni worms from infected mice and its characterization as a host carboxylesterase (2016), Parasitology, 143, 646-657 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| bis-4-nitrophenyl phosphate | BNPP | Mus musculus |  |
| bis-4-nitrophenyl phosphate | BNPP | Rattus norvegicus | |
| PMSF | - |
Mus musculus | |
| PMSF | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | the enzyme is present in soluble form and on the surface of adult Schistosoma mansoni worms in infected mice | Mus musculus | - |
- |
| extracellular | the enzyme is soluble | Rattus norvegicus | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | P23953 | random-bred mice, infected with Schistosoma mansoni | - |
| Rattus norvegicus | P10959 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| purification of a host chymotrypsin-like enzyme present on adult Schistosoma mansoni worms from infected mice, purification of the chymotrypsin-like enzyme from mouse blood plasma by SDS-PAGE | Mus musculus |
| purification of the chymotrypsin-like enzyme from rat blood plasma by SDS-PAGE | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood plasma | - |
Mus musculus | - |
| blood plasma | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| alpha-naphthyl acetate + H2O | - |
Mus musculus | alpha-naphthol + acetate | - |
? | |
| alpha-naphthyl acetate + H2O | - |
Rattus norvegicus | alpha-naphthol + acetate | - |
? | |
| beta-naphthyl acetate + H2O | - |
Mus musculus | beta-naphthol + acetate | - |
? | |
| beta-naphthyl acetate + H2O | - |
Rattus norvegicus | beta-naphthol + acetate | - |
? | |
| N-acetyl-DL-phenylalanine beta-naphthyl ester + H2O | NAPBNE, a chromogenic substrate of chymotrypsin-like enzymes | Mus musculus | N-acetyl-DL-phenylalanine + beta-naphthol | - |
? | |
| N-acetyl-DL-phenylalanine beta-naphthyl ester + H2O | NAPBNE, a chromogenic substrate of chymotrypsin-like enzymes | Rattus norvegicus | N-acetyl-DL-phenylalanine + beta-naphthol | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 85000, about, SDS-PAGE | Mus musculus |
| ? | x * 85000, about, SDS-PAGE | Rattus norvegicus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| carboxylesterase 1C | - |
Mus musculus |
| carboxylesterase 1C | - |
Rattus norvegicus |
| CES 1C | - |
Mus musculus |
| Est1C | - |
Mus musculus |
| Est1C | - |
Rattus norvegicus |
| serine protease-like | - |
Mus musculus |
| serine protease-like | - |
Rattus norvegicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Mus musculus |
| 37 | - |
assay at | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Mus musculus |
| 7.4 | - |
assay at | Rattus norvegicus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | possible role of the enzyme in the mouse host-parasite relationship might be to ease the passage of worms through the host's blood vessels and/or in immune evasion. Immunofluorescent detection of the host-derived enzyme on adult worms | Mus musculus |
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