Cloned (Comment) | Organism |
---|---|
DNA and amino acid sequence analysis | Rattus norvegicus |
DNA and amino acid sequence analysis of isozymes, isozyme genetic structures, location of isozyme PS-PLA1 or PLA1A encoding gene on chromosome 3q13.2-q13.3, phylogenetic analysis of isozymes, overview | Homo sapiens |
DNA and amino acid sequence analysis of isozymes, location of isozyme PS-PLA1 or PLA1A encoding gene on chromosome 16 | Mus musculus |
phylogenetic tree, overview | Cavia porcellus |
phylogenetic tree, overview | Drosophila melanogaster |
Protein Variants | Comment | Organism |
---|---|---|
additional information | gene lpd encoding isozyme mPA-PLA1beta, i.e. the lipid defect locus lipase LPDL, homozygous insertion mutation leads to high levels of triacylglycerols in the plasma and hepatic steatosis | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Drosophila melanogaster | - |
- |
extracellular | - |
Bombyx mori | - |
- |
extracellular | - |
Dolichovespula maculata | - |
- |
extracellular | isozyme PLA1S | Cavia porcellus | - |
- |
extracellular | isozyme PLA1S | Mus musculus | - |
- |
extracellular | isozyme PLA1S | Homo sapiens | - |
- |
extracellular | isozyme PLA1S | Rattus norvegicus | - |
- |
membrane | associated, phosphatidic acid-specific isozymes mPA-PLA1alpha and mPA-PLA1beta | Cavia porcellus | 16020 | - |
membrane | associated, phosphatidic acid-specific isozymes mPA-PLA1alpha and mPA-PLA1beta | Homo sapiens | 16020 | - |
membrane | associated, phosphatidic acid-specific isozymes mPA-PLA1alpha and mPA-PLA1beta | Rattus norvegicus | 16020 | - |
membrane | associated, phosphatidic acid-specific isozymes mPA-PLA1alpha or lipase H, and mPA-PLA1beta or lacrimal lipase | Mus musculus | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | isozyme mPA-PLA1beta is identical to the lipid defect locus lipase LPDL, encoded by gene lpd, homozygous insertion mutation leads to high levels of triacylglycerols in the plasma and hepatic steatosis | ? | - |
? | |
additional information | Mus musculus | isozyme mPA-PLA1beta might plays a role in tumor progression | ? | - |
? | |
phosphatidylcholine + H2O | Cavia porcellus | - |
2-acylglycerophosphocholine + a carboxylate | - |
? | |
phosphatidylcholine + H2O | Drosophila melanogaster | - |
2-acylglycerophosphocholine + a carboxylate | - |
? | |
phosphatidylcholine + H2O | Mus musculus | - |
2-acylglycerophosphocholine + a carboxylate | - |
? | |
phosphatidylcholine + H2O | Homo sapiens | - |
2-acylglycerophosphocholine + a carboxylate | - |
? | |
phosphatidylcholine + H2O | Rattus norvegicus | - |
2-acylglycerophosphocholine + a carboxylate | - |
? | |
phosphatidylcholine + H2O | Bombyx mori | - |
2-acylglycerophosphocholine + a carboxylate | - |
? | |
phosphatidylcholine + H2O | Dolichovespula maculata | - |
2-acylglycerophosphocholine + a carboxylate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bombyx mori | - |
- |
- |
Cavia porcellus | - |
several isozymes | - |
Dolichovespula maculata | - |
hornet | - |
Drosophila melanogaster | - |
- |
- |
Homo sapiens | - |
several isozymes | - |
Mus musculus | - |
several isozymes | - |
Rattus norvegicus | - |
several isozymes | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate | structure-function relationship | Cavia porcellus | |
phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate | structure-function relationship | Drosophila melanogaster | |
phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate | structure-function relationship | Mus musculus | |
phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate | structure-function relationship | Homo sapiens | |
phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate | structure-function relationship | Rattus norvegicus | |
phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate | structure-function relationship | Bombyx mori | |
phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate | structure-function relationship | Dolichovespula maculata |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood platelet | isozyme mPA-PLA1alpha | Mus musculus | - |
blood platelet | isozyme PS-PLA1 or PLA1A | Rattus norvegicus | - |
brain | isozyme mPA-PLA1alpha | Mus musculus | - |
colon | isozyme mPA-PLA1alpha | Mus musculus | - |
endothelium | isozyme endothelial lipase | Cavia porcellus | - |
endothelium | isozyme endothelial lipase | Mus musculus | - |
endothelium | isozyme endothelial lipase | Homo sapiens | - |
endothelium | isozyme endothelial lipase | Rattus norvegicus | - |
heart | isozyme mPA-PLA1alpha | Mus musculus | - |
heart | isozyme PS-PLA1 or PLA1A | Rattus norvegicus | - |
kidney | isozyme mPA-PLA1alpha | Mus musculus | - |
liver | isozyme hepatic lipase | Cavia porcellus | - |
liver | isozyme hepatic lipase | Mus musculus | - |
liver | isozyme hepatic lipase | Homo sapiens | - |
liver | isozyme hepatic lipase | Rattus norvegicus | - |
lung | isozyme mPA-PLA1alpha | Mus musculus | - |
lung | isozyme PS-PLA1 or PLA1A | Rattus norvegicus | - |
mast cell | peritoneal, isozyme PS-PLA1 or PLA1A | Rattus norvegicus | - |
ovary | isozyme mPA-PLA1alpha | Mus musculus | - |
pancreas | pancreatic lipase-related protein 2 | Cavia porcellus | - |
pancreas | pancreatic lipase-related protein 2 | Homo sapiens | - |
pancreas | pancreatic lipase-related protein 2 | Rattus norvegicus | - |
pancreas | pancreatic lipase-related protein 2, isozyme mPA-PLA1alpha | Mus musculus | - |
pancreatic acinar cell | - |
Homo sapiens | - |
pancreatic juice | - |
Homo sapiens | - |
plasma | isozyme mPA-PLA1beta | Homo sapiens | - |
prostate | isozyme mPA-PLA1alpha | Mus musculus | - |
sperm | isozyme mPA-PLA1beta | Mus musculus | - |
spleen | isozyme mPA-PLA1alpha | Mus musculus | - |
testis | isozyme mPA-PLA1alpha and isozyme mPA-PLA1beta | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | isozyme mPA-PLA1beta is identical to the lipid defect locus lipase LPDL, encoded by gene lpd, homozygous insertion mutation leads to high levels of triacylglycerols in the plasma and hepatic steatosis | Homo sapiens | ? | - |
? | |
additional information | isozyme mPA-PLA1beta might plays a role in tumor progression | Mus musculus | ? | - |
? | |
additional information | several isozymes with different substrate specificities, overview, endothelial lipase hepatic lipase, and PLRP2 also exhibit triacylglycerol-hydrolyzing activity | Cavia porcellus | ? | - |
? | |
additional information | several isozymes with different substrate specificities, overview, endothelial lipase hepatic lipase, and PLRP2 also exhibit triacylglycerol-hydrolyzing activity | Mus musculus | ? | - |
? | |
additional information | several isozymes with different substrate specificities, overview, endothelial lipase hepatic lipase, and PLRP2 also exhibit triacylglycerol-hydrolyzing activity | Homo sapiens | ? | - |
? | |
additional information | several isozymes with different substrate specificities, overview, endothelial lipase hepatic lipase, and PLRP2 also exhibit triacylglycerol-hydrolyzing activity | Rattus norvegicus | ? | - |
? | |
phosphatidic acid + H2O | phosphatidic acid-specific isozymes mPA-PLA1alpha and mPA-PLA1beta | Cavia porcellus | ? | - |
? | |
phosphatidic acid + H2O | phosphatidic acid-specific isozymes mPA-PLA1alpha and mPA-PLA1beta | Homo sapiens | ? | - |
? | |
phosphatidic acid + H2O | phosphatidic acid-specific isozymes mPA-PLA1alpha and mPA-PLA1beta | Rattus norvegicus | ? | - |
? | |
phosphatidic acid + H2O | phosphatidic acid-specific isozymes mPA-PLA1alpha and mPA-PLA1beta | Mus musculus | 2-acyllysophosphatidic acid + a carboxylate | - |
? | |
phosphatidylcholine + H2O | - |
Cavia porcellus | 2-acylglycerophosphocholine + a carboxylate | - |
? | |
phosphatidylcholine + H2O | - |
Drosophila melanogaster | 2-acylglycerophosphocholine + a carboxylate | - |
? | |
phosphatidylcholine + H2O | - |
Mus musculus | 2-acylglycerophosphocholine + a carboxylate | - |
? | |
phosphatidylcholine + H2O | - |
Homo sapiens | 2-acylglycerophosphocholine + a carboxylate | - |
? | |
phosphatidylcholine + H2O | - |
Rattus norvegicus | 2-acylglycerophosphocholine + a carboxylate | - |
? | |
phosphatidylcholine + H2O | - |
Bombyx mori | 2-acylglycerophosphocholine + a carboxylate | - |
? | |
phosphatidylcholine + H2O | - |
Dolichovespula maculata | 2-acylglycerophosphocholine + a carboxylate | - |
? | |
phosphatidylserine + H2O | phosphatidylserine-specific PLA1 isozyme PS-PLA1 or PLA1A | Cavia porcellus | ? | - |
? | |
phosphatidylserine + H2O | phosphatidylserine-specific PLA1 isozyme PS-PLA1 or PLA1A | Mus musculus | ? | - |
? | |
phosphatidylserine + H2O | phosphatidylserine-specific PLA1 isozyme PS-PLA1 or PLA1A | Homo sapiens | ? | - |
? | |
phosphatidylserine + H2O | phosphatidylserine-specific PLA1 isozyme PS-PLA1 or PLA1A | Rattus norvegicus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | amino acid sequence comparison | Dolichovespula maculata |
More | isozyme tertiary structure analysis, amino acid sequence comparison | Homo sapiens |
More | isozyme tertiary structure analysis, amino acid sequence comparison, overview | Cavia porcellus |
More | isozyme tertiary structure analysis, overview | Drosophila melanogaster |
More | isozyme tertiary structure analysis, overview | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
endothelial lipase | - |
Cavia porcellus |
endothelial lipase | - |
Mus musculus |
endothelial lipase | - |
Homo sapiens |
endothelial lipase | - |
Rattus norvegicus |
hepatic lipase | - |
Cavia porcellus |
hepatic lipase | - |
Mus musculus |
hepatic lipase | - |
Homo sapiens |
hepatic lipase | - |
Rattus norvegicus |
lacrimal lipase | - |
Mus musculus |
lipase H | - |
Mus musculus |
More | the enzyme belongs to the pancreatic lipase gene family | Drosophila melanogaster |
More | the enzyme belongs to the pancreatic lipase gene family | Bombyx mori |
More | the enzyme belongs to the pancreatic lipase gene family | Dolichovespula maculata |
More | the isozymes belong to the pancreatic lipase gene family or to the phospholipase family | Cavia porcellus |
More | the isozymes belong to the pancreatic lipase gene family or to the phospholipase family | Mus musculus |
More | the isozymes belong to the pancreatic lipase gene family or to the phospholipase family | Homo sapiens |
More | the isozymes belong to the pancreatic lipase gene family or to the phospholipase family | Rattus norvegicus |
mPA-PLA1alpha | - |
Cavia porcellus |
mPA-PLA1alpha | - |
Mus musculus |
mPA-PLA1alpha | - |
Homo sapiens |
mPA-PLA1alpha | - |
Rattus norvegicus |
mPA-PLA1beta | - |
Cavia porcellus |
mPA-PLA1beta | - |
Mus musculus |
mPA-PLA1beta | - |
Homo sapiens |
mPA-PLA1beta | - |
Rattus norvegicus |
pancreatic lipase-related protein 2 | - |
Cavia porcellus |
pancreatic lipase-related protein 2 | - |
Mus musculus |
pancreatic lipase-related protein 2 | - |
Homo sapiens |
pancreatic lipase-related protein 2 | - |
Rattus norvegicus |
PLA1 | - |
Cavia porcellus |
PLA1 | - |
Drosophila melanogaster |
PLA1 | - |
Mus musculus |
PLA1 | - |
Homo sapiens |
PLA1 | - |
Rattus norvegicus |
PLA1 | - |
Bombyx mori |
PLA1 | - |
Dolichovespula maculata |
PLA1S | - |
Cavia porcellus |
PLA1S | - |
Mus musculus |
PLA1S | - |
Homo sapiens |
PLA1S | - |
Rattus norvegicus |
PLRP2 | - |
Cavia porcellus |
PLRP2 | - |
Mus musculus |
PLRP2 | - |
Homo sapiens |
PLRP2 | - |
Rattus norvegicus |