Activating Compound | Comment | Organism | Structure |
---|---|---|---|
angiopoietin-like protein 4 | major physiological regulator of enzyme activity under conditions of fasting and exercise | Mus musculus | |
apolipoprotein A5 | - |
Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ANGPTL4 | conventional, non-competitive inhibitor | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
triacylglycerol + H2O | Mus musculus | - |
diacylglycerol + a carboxylate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
brown adipose tissue | - |
Mus musculus | - |
heart | - |
Mus musculus | - |
kidney | - |
Mus musculus | - |
liver | - |
Mus musculus | - |
lung | - |
Mus musculus | - |
macrophage | - |
Mus musculus | - |
mammary gland | - |
Mus musculus | - |
skeletal muscle | - |
Mus musculus | - |
white adipose tissue | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
triacylglycerol + H2O | - |
Mus musculus | diacylglycerol + a carboxylate | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | - |
Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
LPL | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | stress and catecholamines reduce adipose enzyme activity. Tissue necrosis factpor alpha represses enzyme activity by downregulating transcription | down |
Mus musculus | insulin, dexamethasone and cortisol increase mRNA and activity in adipose organs. Cold markedly stimulates enzyme activity in brown adipose tissue | up |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme is rate limiting for plasma triglyceride clearance and tissue uptake of fatty acids | Mus musculus |