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Literature summary for 3.1.1.34 extracted from

  • Mahat, B.; Chasse, E.; Mauger, J.F.; Imbeault, P.
    Effects of acute hypoxia on human adipose tissue lipoprotein lipase activity and lipolysis (2016), J. Transl. Med., 14, 212 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
triacylglycerol + H2O Homo sapiens
-
 diacylglycerol + a carboxylate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P06858
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adipose tissue
-
 Homo sapiens
-
preadipocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
triacylglycerol + H2O
-
 Homo sapiens diacylglycerol + a carboxylate
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Homo sapiens

General Information

General Information Comment Organism
malfunction acute hypoxia strongly inhibits lipoprotein lipase activity in differentiated human preadipocytes and increases non-esterified fatty acid release, adversely affecting postprandial lipemia. In differentiated preadipocytes, acute hypoxia induces a 6fold reduction in lipoprotein lipase activity. Acute intermittent hypoxia increases circulating plasma non-esterified fatty acid in young healthy men, but does not seem to affect postprandial triglyceride levels, nor subcutaneous abdominal adipose tissue lipoprotein lipase activity and adipocyte lipolysis. The reduction in adipose tissue LPL activity appears to be explained by the upregulation of an important posttranslational repressor of LPL, angiopoietin-like protein 4 (ANGPTL4) Homo sapiens
physiological function adipose tissue regulates postprandial lipid metabolism by storing dietary fat through lipoprotein lipase-mediated hydrolysis of exogenous triglycerides, and by inhibiting delivery of endogenous non-esterified fatty acid to nonadipose tissues. In humans, the rise in postprandial triglyceride levels does not differ between normoxia and intermittent hypoxia. Nonesterified fatty acid levels are higher during intermittent hypoxia session. Intermittent hypoxia does not affect subcutaneous abdominal adipose tissue lipoprotein lipase activity. No differences are observed in lipolytic responses of isolated subcutaneous abdominal adipocytes between normoxia and intermittent hypoxia sessions Homo sapiens