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Literature summary for 3.1.1.34 extracted from

  • Zemankova, K.; Makoveichuk, E.; Vlasakova, Z.; Olivecrona, G.; Kovar, J.
    Acute alcohol consumption downregulates lipoprotein lipase activity in vivo (2015), Metab. Clin. Exp., 64, 1592-1596 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
angiopoietin-like protein 3 ANGPTL3 inhibits the enzyme. The concentrations of inhibitor ANGPTL3 drops to 67% of baseline value at 280 min after alcohol consumption Homo sapiens
angiopoietin-like protein 4 ANGPTL4 inhibits the enzyme. The concentrations of inhibitor ANGPTL4 drops to 86% of baseline value at 280 min after alcohol consumption Homo sapiens
ethanol inhibits the enzyme, LPL activity is reduced by 23-25% 2-4 hours after the administration of alcohol, respectively, with respect to controls, in vivo or in post-heparin plasma. The concentrations of inhibitors ANGPTL3 and ANGPTL4 drops to 67% and 86% of baseline values, respectively, at 280 min after alcohol consumption. The acute effects of alcohol consumption, especially on postprandial lipemia, seem to be accentuated in hypertriglyceridemic subjects Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
triacylglycerol + H2O Homo sapiens
-
diacylglycerol + a carboxylate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P06858
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
triacylglycerol + H2O
-
Homo sapiens diacylglycerol + a carboxylate
-
?

Synonyms

Synonyms Comment Organism
LPL
-
Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme is the key enzyme responsible for intravascular triglyceride lipolysis. The acute alcohol consumption can induce hypertriglyceridemia, partly by influencing of lipoprotein lipase (LPL) through alcohol. LPL is the key enzyme responsible for triglyceride hydrolysis in circulation. The acute effects of alcohol consumption, especially on postprandial lipemia, seem to be accentuated in hypertriglyceridemic subjects Homo sapiens