Cloned (Comment) | Organism |
---|---|
gene Lpl, quantitative real-time PCR enzyme expression analysis | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
triacylglycerol + H2O | Homo sapiens | - |
diacylglycerol + a carboxylate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P06858 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adipose tissue | - |
Homo sapiens | - |
additional information | adipose tissue LPL activity is markedly higher than placental LPL activity. In pregnant women, adipose tissue LPL activity, which hydrolyzes triglycerides to free fatty acids for uptake into maternal fat, is not correlated with body weight or newborn adiposity | Homo sapiens | - |
placenta | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
triacylglycerol + H2O | - |
Homo sapiens | diacylglycerol + a carboxylate | - |
? | |
triacylglycerol + H2O | a 14C-triolein phosphatidylcholine-stabilized substrate containing ApoC2 is used for in vitro enzyme activity assays | Homo sapiens | diacylglycerol + a carboxylate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
adipose tissue LPL | - |
Homo sapiens |
LPL | - |
Homo sapiens |
placental lipoprotein lipase | - |
Homo sapiens |
pLPL | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | placental lipoprotein lipase activity is positively associated with newborn adiposity. Placental lipoprotein lipase (pLPL) hydrolyzes triglycerides (TG), both dietary chylomicron TG (CM-TG) and very-low density lipoprotein TG (VLDL-TG), to free fatty acids (FFA). This may promote fetal fat accretion by increasing the available FFA pool for placental uptake. pLPL activity, but not maternal adipose tissue LPL activity, is associated with newborn adiposity and higher maternal TG. Placental LPL activity is positively correlated with birthweight and newborn percent body fat, but maternal adipose tissue LPL is not. Maternal TG and BMI are not correlated with pLPL. pLPL gene expression, while modestly correlated with enzymatic activity, is not correlated with newborn adiposity. Placental lipase regulation and the role of pLPL in pregnancies, overview | Homo sapiens |