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Literature summary for 3.1.1.4 extracted from

  • Yang, H-C.; Mosior, M.; Ni, B.; Dennis, E.A.
    Regional distribution, ontogeny, purification, and characterization of the Ca2+-independent phospholipase A2 from rat brain (1999), J. Neurochem., 73, 1278-1287.
    View publication on PubMed
Search for more literature for 3.1.1.4

Inhibitors

Inhibitors Comment Organism Structure
pure phospholipid vesicles exception: vesicles composed of phosphatidylcholine or phosphatidylinositol 4,5-bisphosphate Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Rattus norvegicus 5737
-
secretory granule
-
 Rattus norvegicus 30141
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+
-
 Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
80000
-
 SDS-PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phospholipids + H2O Rattus norvegicus influence on platelet aggregation ?
-
 ?
phospholipids + H2O Rattus norvegicus release of arachidonic acid: biosynthesis of leucotrienes, thromboxans and prostaglandins ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
30000fold from rat brain, 90% pure protein Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain iPLA2 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.6
-
 iPLA2 in a 30000fold purification, substrate: 1-stearoyl-2-arachidonoylphosphatidylcholine Rattus norvegicus
2
-
 iPLA2 in a 30000fold purification, substrate: 1-palmitoyl-2-arachidonoylphosphatidylcholine Rattus norvegicus
3
-
 iPLA2 in a 30000fold purification, substrate: 1-palmitoyl-2-oleolylphosphatidylcholine Rattus norvegicus
4.3
-
 iPLA2 in a 30000fold purification, substrate: 1,2-dipalmitoyl-phosphatidylcholine Rattus norvegicus
5.9
-
 iPLA2 in a 30000fold purification, substrate: 1-palmitoyl-2-linoleoylphosphatidylethanolamine Rattus norvegicus
10
-
 iPLA2 in a 30000fold purification, substrate: 1-palmitoyl-2-linoleoylphosphatidylcholine Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1,2-dipalmitoyl-phosphatidylcholine + H2O data for iPLA2 Rattus norvegicus 1-palmitoyl-glycerophosphorylcholine + palmitic acid
-
 ?
1-palmitoyl-2-arachidonoylphosphatidylcholine + H2O ,data for iPLA2 Rattus norvegicus 1-palmitoyl-glycerophosphorylcholine + arachidonic acid
-
 ?
1-palmitoyl-2-linoleoylphosphatidylcholine + H2O iPLA2 Rattus norvegicus 1-palmitoyl-glycerophosphorylcholine + linolic acid
-
 ?
1-palmitoyl-2-linoleoylphosphatidylethanolamine + H2O data for iPLA2 Rattus norvegicus 1-palmitoyl-glycerophosphorylethanolamine + linolic acid
-
 ?
1-palmitoyl-2-oleoylphosphatidylcholine + H2O data for iPLA2 Rattus norvegicus 1-palmitoyl-glycerophosphocholine + oleic acid
-
 ?
1-stearoyl-2-arachidonoylphosphatidylcholine + H2O data for iPLA2 Rattus norvegicus 1-stearoyl-glycerophosphorylcholine + arachidonic acid
-
 ?
phospholipids + H2O influence on platelet aggregation Rattus norvegicus ?
-
 ?
phospholipids + H2O release of arachidonic acid: biosynthesis of leucotrienes, thromboxans and prostaglandins Rattus norvegicus ?
-
 ?