Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.1.4 extracted from

  • Pande, A.H.; Qin, S.; Nemec, K.N.; He, X.; Tatulian, S.A.
    Isoform-specific membrane insertion of secretory phospholipase A2 and functional implications (2006), Biochemistry, 45, 12436-12447.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information isozyme-specific membrane insertion of secretory phospholipase A2 is controlled by membrane fluidity and is necessary for the full activity of the enzyme, overview Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression of isozyme hIBPLA2 and wild-type and mutant isozymes hIIAPLA2 in Escherichia coli strain BL21(DE3) Homo sapiens

Protein Variants

Protein Variants Comment Organism
V3W site-directed mutagenesis, mutant of human group IIA PLA2, structure comparison to isozyme human group IB PLA2 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information kinetics of recombinant wild-type and mutant enzymes Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
Apis mellifera
-
-
extracellular secretory phospholipase A2 Homo sapiens
-
-
membrane isozyme-specific membrane insertion of secretory phospholipase A2 is controlled by membrane fluidity and is necessary for the full activity of the enzyme, membrane anionic surface charge facilitates membrane Recruitment and ActiVity of hIBPLA2, overview Homo sapiens 16020
-

Organism

Organism UniProt Comment Textmining
Apis mellifera P00630
-
-
Homo sapiens P14555
-
-

Purification (Commentary)

Purification (Comment) Organism
native enzyme from venom by gel filtration to homogeneity Apis mellifera
recombinant human group IIA PLA2isozyme and isozyme hIBPLA2 from Escherichia coli strain BL21(DE3) Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
venom
-
Apis mellifera
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1,2-bis-(10-pyrenedecanoyl)-sn-glycero-3-phosphocholine + H2O
-
Apis mellifera 1-(10-pyrenedecanoyl)-glycero-3-phosphocholine + 10-pyrenedecanoate
-
?
1,2-bis-(10-pyrenedecanoyl)-sn-glycero-3-phosphocholine + H2O
-
Homo sapiens 1-(10-pyrenedecanoyl)-glycero-3-phosphocholine + 10-pyrenedecanoate
-
?
1,2-dipalmitoyl-sn-glycero-3-phosphocholine + H2O
-
Apis mellifera 1-palmitoyl-sn-glycero-3-phosphorylcholine + palmitate
-
?
1,2-dipalmitoyl-sn-glycero-3-phosphocholine + H2O
-
Homo sapiens 1-palmitoyl-sn-glycero-3-phosphorylcholine + palmitate
-
?
1,2-dipalmitoyl-sn-glycero-3-phosphoglycerol + H2O
-
Homo sapiens 1-palmitoyl-glycero-3-phosphoglycerol + palmitate
-
?
1,2-dipalmitoyl-sn-glycero-3-phosphoglycerol + H2O
-
Apis mellifera 1-palmitoyl-sn-glycero-3-phosphorylglycerol + palmitate
-
?
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine + H2O
-
Apis mellifera 1-palmitoyl-sn-glycero-3-phosphocholine + oleate
-
?
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine + H2O
-
Homo sapiens 1-palmitoyl-sn-glycero-3-phosphocholine + oleate
-
?
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol + H2O
-
Apis mellifera 1-palmitoyl-sn-glycero-3-phosphorylglycerol + oleate
-
?
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol + H2O
-
Homo sapiens 1-palmitoyl-sn-glycero-3-phosphorylglycerol + oleate
-
?
1-palmitoyl-2-stearoyl-dibromo-sn-glycero-3-phosphocholine + H2O
-
Apis mellifera ?
-
?
1-palmitoyl-2-stearoyl-dibromo-sn-glycero-3-phosphocholine + H2O
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
hIBPLA2
-
Homo sapiens
hIIAPLA2
-
Homo sapiens
human group IB PLA2
-
Homo sapiens
PLA2
-
Apis mellifera
secretory phospholipase A2
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Apis mellifera
25
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Apis mellifera
7.4
-
assay at Homo sapiens