Protein Variants | Comment | Organism |
---|---|---|
H48Q | site-directed mutagenesis, inactive catalytic site mutant | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine | competitive inhibition of platelet activating factor hydrolysis | Homo sapiens | |
EDTA | 95% inhibition at 5 mM | Homo sapiens | |
LY 329722 | i.e. 3-(3-aminooxalyl-1-benzyl-2-ethyl-6-methyl-1H-indol-4-yl)propionic acid | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | the enzyme is secreted | Homo sapiens | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | dependent on | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphatidylcholine + H2O | Homo sapiens | - |
1-acylglycerophosphocholine + a carboxylate | - |
? | |
platelet activating factor + H2O | Homo sapiens | hGX sPLA2 hydrolyzes platelet activating factor, which is a reaction catalyzed by the platelet activating factor-acetylhydrolase, EC 3.1.1.47 | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.14 | - |
substrate 1-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine | Homo sapiens |
8.56 | - |
substrate 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O | i.e. PAF or platelet activating factor | Homo sapiens | 1-hexadecanoyl-glycero-3-phosphoglycerol + acetate | - |
? | |
1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine + H2O | - |
Homo sapiens | 1-palmitoyl-glycero-3-phosphocholine + arachidonate | - |
? | |
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine + H2O | preferred substrate | Homo sapiens | 1-palmitoyl-sn-glycero-3-phosphocholine + oleate | - |
? | |
additional information | hGX sPLA2 prefers phosphatidylcholine 50fold to 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine as substrate, its hydrolyzing activity towards platelet activating factor rises abruptly when the concentration of the substrate passes through its critical micelle concentration, overview | Homo sapiens | ? | - |
? | |
phosphatidylcholine + H2O | - |
Homo sapiens | 1-acylglycerophosphocholine + a carboxylate | - |
? | |
platelet activating factor + H2O | hGX sPLA2 hydrolyzes platelet activating factor, which is a reaction catalyzed by the platelet activating factor-acetylhydrolase, EC 3.1.1.47 | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
hGX sPLA2 | - |
Homo sapiens |
More | the enzyme is a group X secreted phospholipase A2 | Homo sapiens |
PLA2 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |