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Literature summary for 3.1.1.4 extracted from

  • Kita, Y.; Ohto, T.; Uozumi, N.; Shimizu, T.
    Biochemical properties and pathophysiological roles of cytosolic phospholipase A2s (2006), Biochim. Biophys. Acta, 1761, 1317-1322.
    View publication on PubMed
Search for more literature for 3.1.1.4

Cloned(Commentary)

Cloned (Comment) Organism
chromosomal location at 1G1, phylogenetic tree Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information construction of cytosolic PLA2 null mutant mice, phenotype, e.g. with loss of renal concentration function, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Mus musculus 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ required Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phospholipid + H2O Mus musculus the enzyme is essential for production of two classes of lipid mediators, fatty acid metabolites, and lysophospholipid-related lipids, and is involved in the remodeling of membrane phospholipids, physiologic functions, overview lysophospholipid + fatty acid
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P47713
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein the enzyme contains phosphorylation sites at Ser505, Ser515, and Ser727 Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phospholipid + H2O
-
 Mus musculus lysophospholipid + fatty acid
-
 ?
phospholipid + H2O the enzyme is essential for production of two classes of lipid mediators, fatty acid metabolites, and lysophospholipid-related lipids, and is involved in the remodeling of membrane phospholipids, physiologic functions, overview Mus musculus lysophospholipid + fatty acid
-
 ?

Subunits

Subunits Comment Organism
? x * 85000-110000, about, SDS-PAGE Mus musculus
More the enzyme contains a catalytic lipase domain and a C2 CaLB domain, domain structure, overview Mus musculus

Synonyms

Synonyms Comment Organism
cPLA2
-
 Mus musculus
cytosolic phospholipase A2
-
 Mus musculus
More the cytosolic PLA2 belongs to the group IV PLA2s Mus musculus