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Literature summary for 3.1.1.4 extracted from

  • Bailey, R.W.; Olson, E.D.; Vu, M.P.; Brueseke, T.J.; Robertson, L.; Christensen, R.E.; Parker, K.H.; Judd, A.M.; Bell, J.D.
    Relationship between membrane physical properties and secretory phospholipase A2 hydrolysis kinetics in S49 cells during ionophore-induced apoptosis (2007), Biophys. J., 93, 2350-2362.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.1.4

Activating Compound

Activating Compound Comment Organism Structure
additional information in apoptosis the initial rate of hydrolysis is elevated at all enzyme concentrations, the total amount of reaction product is increased fourfold, and adsorption of the enzyme to the membrane surface is unaltered Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information kinetics of interaction between sPLA2 and lymphocyte cell membranes, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Mus musculus
-
-
membrane
-
 Mus musculus 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus during apoptosis, changes occur in lymphocyte membranes that render them susceptible to hydrolysis by secretory phospholipase A2, mechanism, the membranes of apoptotic cells become susceptible to sPLA2 through a reduction in lipid-neighbor interactions that facilitates migration of phospholipids into the enzyme active site, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lymphocyte
-
 Mus musculus
-
lymphoma cell
-
 Mus musculus
-
S49 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information during apoptosis, changes occur in lymphocyte membranes that render them susceptible to hydrolysis by secretory phospholipase A2, mechanism, the membranes of apoptotic cells become susceptible to sPLA2 through a reduction in lipid-neighbor interactions that facilitates migration of phospholipids into the enzyme active site, overview Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
secretory phospholipase A2
-
 Mus musculus
sPLA2
-
 Mus musculus