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Literature summary for 3.1.1.4 extracted from

  • Davis, B.; Koster, G.; Douet, L.J.; Scigelova, M.; Woffendin, G.; Ward, J.M.; Smith, A.; Humphres, J.; Burnand, K.G.; Macphee, C.H.; Postle, A.D.
    Electrospray ionization mass spectrometry identifies substrates and products of lipoprotein-associated phospholipase A2 in oxidized human low density lipoprotein (2007), J. Biol. Chem., 283, 6428-6437.
    View publication on PubMed

Application

Application Comment Organism
drug development development of Lp-PLA2 inhibitors as therapy for atherosclerosis Homo sapiens
pharmacology development of Lp-PLA2 inhibitors as therapy for atherosclerosis Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
SB222657
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphatidylcholine + H2O Homo sapiens the lipoprotein-associated phospholipase A2 is present in vulnerable plaque regions where it acts on LDL phospholipid oxidation products to generate the pro-inflammatory lysophospholipids and oxidized non-esterified fatty acids, it predominantly circulates as a constituent of LDL particles, overview 1-acylglycerophosphocholine + a carboxylate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information the lipoprotein-associated phospholipase A2 is present in vulnerable plaque regions of blood vessels, it predominantly circulates as a constituent of LDL particles Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information long chain oxidized phosphatidylcholines represent quantitatively the most abundant phosphatidylcholine products of LDL oxidation, although they are less efficient as substrates for Lp-PLA2 than are the short chain oxidized phosphoatidylcholines Homo sapiens ?
-
?
phosphatidylcholine + H2O the lipoprotein-associated phospholipase A2 is present in vulnerable plaque regions where it acts on LDL phospholipid oxidation products to generate the pro-inflammatory lysophospholipids and oxidized non-esterified fatty acids, it predominantly circulates as a constituent of LDL particles, overview Homo sapiens 1-acylglycerophosphocholine + a carboxylate
-
?
phosphatidylcholine + H2O substrate is derived from human carotid artery plaques Homo sapiens 1-acylglycerophosphocholine + a carboxylate
-
?

Synonyms

Synonyms Comment Organism
lipoprotein-associated phospholipase A2
-
Homo sapiens
Lp-PLA2
-
Homo sapiens
More cf. EC 3.1.1.34 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens