Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(+-)-3-O-[4-(4,5-dihydro-5-oxo-1,2,4-4H-oxadiazol-3-yl)phenyl]-2-O-tetradecyl-1-O-triphenylmethylglycerol | - |
Homo sapiens | |
(+-)-3-O-[4-(4,5-dihydro-5-oxo-1,2,4-4H-oxadiazol-3-yl)phenyl]-2-O-tetradecyl-1-O-triphenylmethylglycerol | - |
Sus scrofa | |
3,3'-[[2-(pentyloxy)propane-1,3-diyl]bis(oxybenzene-4,1-diylethane-2,1-diyl)]bis(1,2,4-oxadiazol-5(4H)-one) | - |
Homo sapiens | |
3,3'-[[2-(pentyloxy)propane-1,3-diyl]bis(oxybenzene-4,1-diylethane-2,1-diyl)]bis(1,2,4-oxadiazol-5(4H)-one) | - |
Sus scrofa | |
3,3'-[[2-(tetradecyloxy)propane-1,3-diyl]bis(oxybenzene-4,1-diylethane-2,1-diyl)]bis(1,2,4-oxadiazol-5(4H)-one) | - |
Homo sapiens | |
3,3'-[[2-(tetradecyloxy)propane-1,3-diyl]bis(oxybenzene-4,1-diylethane-2,1-diyl)]bis(1,2,4-oxadiazol-5(4H)-one) | - |
Sus scrofa | |
3,3'-[[2-(tetradecyloxy)propane-1,3-diyl]bis(oxybenzene-4,1-diylmethanediyl)]bis(1,2,4-oxadiazol-5(4H)-one) | - |
Homo sapiens | |
3,3'-[[2-(tetradecyloxy)propane-1,3-diyl]bis(oxybenzene-4,1-diylmethanediyl)]bis(1,2,4-oxadiazol-5(4H)-one) | - |
Sus scrofa | |
3,3'-[[3-(tetradecyloxy)propane-1,2-diyl]bis(oxybenzene-4,1-diylethane-2,1-diyl)]bis(1,2,4-oxadiazol-5(4H)-one) | - |
Homo sapiens | |
3,3'-[[3-(tetradecyloxy)propane-1,2-diyl]bis(oxybenzene-4,1-diylethane-2,1-diyl)]bis(1,2,4-oxadiazol-5(4H)-one) | - |
Sus scrofa | |
3,3'-[[3-(tetradecyloxy)propane-1,2-diyl]bis(oxybenzene-4,1-diylmethanediyl)]bis(1,2,4-oxadiazol-5(4H)-one) | - |
Homo sapiens | |
3,3'-[[3-(tetradecyloxy)propane-1,2-diyl]bis(oxybenzene-4,1-diylmethanediyl)]bis(1,2,4-oxadiazol-5(4H)-one) | - |
Sus scrofa | |
3-[4-[3-(4-butylphenoxy)-2-(tetradecyloxy)propoxy]benzyl]-1,2,4-oxadiazol-5(4H)-one | - |
Homo sapiens | |
3-[4-[3-(4-butylphenoxy)-2-(tetradecyloxy)propoxy]benzyl]-1,2,4-oxadiazol-5(4H)-one | - |
Sus scrofa | |
3-[4-[3-(4-methylphenoxy)-2-(tetradecyloxy)propoxy]benzyl]-1,2,4-oxadiazol-5(4H)-one | - |
Homo sapiens | |
3-[4-[3-(4-methylphenoxy)-2-(tetradecyloxy)propoxy]benzyl]-1,2,4-oxadiazol-5(4H)-one | - |
Sus scrofa | |
3-[4-[3-(decyloxy)-2-(tetradecyloxy)propoxy]benzyl]-1,2,4-oxadiazol-5(4H)-one | - |
Homo sapiens | |
3-[4-[3-(decyloxy)-2-(tetradecyloxy)propoxy]benzyl]-1,2,4-oxadiazol-5(4H)-one | - |
Sus scrofa | |
3-[4-[3-(diphenylmethoxy)-2-(tetradecyloxy)propoxy]benzyl]-1,2,4-oxadiazol-5(4H)-one | - |
Homo sapiens | |
3-[4-[3-(diphenylmethoxy)-2-(tetradecyloxy)propoxy]benzyl]-1,2,4-oxadiazol-5(4H)-one | - |
Sus scrofa | |
3-[4-[3-(pentyloxy)-2-(tetradecyloxy)propoxy]benzyl]-1,2,4-oxadiazol-5(4H)-one | - |
Homo sapiens | |
3-[4-[3-(pentyloxy)-2-(tetradecyloxy)propoxy]benzyl]-1,2,4-oxadiazol-5(4H)-one | - |
Sus scrofa | |
3-[4-[3-ethoxy-2-(tetradecyloxy)propoxy]benzyl]-1,2,4-oxadiazol-5(4H)-one | - |
Homo sapiens | |
3-[4-[3-ethoxy-2-(tetradecyloxy)propoxy]benzyl]-1,2,4-oxadiazol-5(4H)-one | - |
Sus scrofa | |
Me-Indoxam | - |
Homo sapiens | |
Me-Indoxam | - |
Sus scrofa | |
additional information | inhibitor synthesis and screening, overview, inhibitory potency of 3-[4-[3-ethoxy-2-(tetradecyloxy)propoxy]benzyl]-1,2,4-oxadiazol-5(4H)-one derivatives with the different isozymes, overview | Homo sapiens | |
additional information | inhibitor screening, overview, inhibitory potency of 3-[4-[3-ethoxy-2-(tetradecyloxy)propoxy]benzyl]-1,2,4-oxadiazol-5(4H)-one derivatives, overview | Sus scrofa |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Homo sapiens | - |
- |
extracellular | - |
Sus scrofa | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozymes hGIIA sPLA2, hGIB sPLA2, hGX sPLA2, and hGV sPLA2 | - |
Sus scrofa | - |
isozyme hGIB sPLA2 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | from pancreas | Sus scrofa | - |
pancreas | - |
Sus scrofa | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(+/-)-3-O-(4-cyanomethylphenyl)-1,2-O-di-n-heptylglycerol + H2O | - |
Homo sapiens | ? | - |
? | |
(+/-)-3-O-(4-cyanomethylphenyl)-1,2-O-di-n-heptylglycerol + H2O | - |
Sus scrofa | ? | - |
? | |
(+/-)-3-O-(4-hydroxymethylphenyl)-1,2-O-di-n-heptylglycerol + H2O | - |
Homo sapiens | ? | - |
? | |
(+/-)-3-O-(4-hydroxymethylphenyl)-1,2-O-di-n-heptylglycerol + H2O | - |
Sus scrofa | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PLA2 | - |
Homo sapiens |
PLA2 | - |
Sus scrofa |
secreted phospholipase A2 | - |
Homo sapiens |
secreted phospholipase A2 | - |
Sus scrofa |
sPLA2 | - |
Homo sapiens |
sPLA2 | - |
Sus scrofa |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |
7.5 | - |
assay at | Sus scrofa |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
additional information | - |
- |
Homo sapiens | additional information | |
0.00028 | - |
pH 7.5, isozyme hGIIA sPLA2 | Homo sapiens | 3-[4-[3-(decyloxy)-2-(tetradecyloxy)propoxy]benzyl]-1,2,4-oxadiazol-5(4H)-one | |
0.00028 | - |
pH 7.5, isozyme hGIIA sPLA2 | Homo sapiens | 3-[4-[3-(diphenylmethoxy)-2-(tetradecyloxy)propoxy]benzyl]-1,2,4-oxadiazol-5(4H)-one | |
0.00029 | - |
pH 7.5, isozyme hGIIA sPLA2 | Homo sapiens | 3-[4-[3-(4-butylphenoxy)-2-(tetradecyloxy)propoxy]benzyl]-1,2,4-oxadiazol-5(4H)-one | |
0.00055 | - |
pH 7.5, isozyme hGV sPLA2 | Homo sapiens | 3-[4-[3-(decyloxy)-2-(tetradecyloxy)propoxy]benzyl]-1,2,4-oxadiazol-5(4H)-one | |
0.0007 | - |
pH 7.5, isozyme hGV sPLA2 | Homo sapiens | (+-)-3-O-[4-(4,5-dihydro-5-oxo-1,2,4-4H-oxadiazol-3-yl)phenyl]-2-O-tetradecyl-1-O-triphenylmethylglycerol | |
0.0009 | - |
pH 7.5, isozyme hGIIA sPLA2 | Homo sapiens | (+-)-3-O-[4-(4,5-dihydro-5-oxo-1,2,4-4H-oxadiazol-3-yl)phenyl]-2-O-tetradecyl-1-O-triphenylmethylglycerol | |
0.001 | - |
pH 7.5, isozyme hGX sPLA2 | Homo sapiens | 3-[4-[3-(decyloxy)-2-(tetradecyloxy)propoxy]benzyl]-1,2,4-oxadiazol-5(4H)-one | |
0.0013 | - |
pH 7.5, isozyme hGX sPLA2 | Homo sapiens | (+-)-3-O-[4-(4,5-dihydro-5-oxo-1,2,4-4H-oxadiazol-3-yl)phenyl]-2-O-tetradecyl-1-O-triphenylmethylglycerol | |
0.002 | - |
pH 7.5, isozyme hGV sPLA2 | Homo sapiens | 3-[4-[3-(diphenylmethoxy)-2-(tetradecyloxy)propoxy]benzyl]-1,2,4-oxadiazol-5(4H)-one | |
0.0021 | - |
pH 7.5, isozyme hGIIA sPLA2 | Homo sapiens | 3,3'-[[2-(tetradecyloxy)propane-1,3-diyl]bis(oxybenzene-4,1-diylethane-2,1-diyl)]bis(1,2,4-oxadiazol-5(4H)-one) | |
0.0022 | - |
pH 7.5, isozyme hGIB sPLA2 | Sus scrofa | 3-[4-[3-(4-butylphenoxy)-2-(tetradecyloxy)propoxy]benzyl]-1,2,4-oxadiazol-5(4H)-one | |
0.0031 | - |
pH 7.5, isozyme hGIIA sPLA2 | Homo sapiens | 3,3'-[[3-(tetradecyloxy)propane-1,2-diyl]bis(oxybenzene-4,1-diylethane-2,1-diyl)]bis(1,2,4-oxadiazol-5(4H)-one) | |
0.0053 | - |
pH 7.5, isozyme hGX sPLA2 | Homo sapiens | 3-[4-[3-(diphenylmethoxy)-2-(tetradecyloxy)propoxy]benzyl]-1,2,4-oxadiazol-5(4H)-one | |
0.0056 | - |
pH 7.5, isozyme hGIB sPLA2 | Sus scrofa | 3-[4-[3-(diphenylmethoxy)-2-(tetradecyloxy)propoxy]benzyl]-1,2,4-oxadiazol-5(4H)-one | |
0.0058 | - |
pH 7.5, isozyme hGIB sPLA2 | Homo sapiens | (+-)-3-O-[4-(4,5-dihydro-5-oxo-1,2,4-4H-oxadiazol-3-yl)phenyl]-2-O-tetradecyl-1-O-triphenylmethylglycerol | |
0.0083 | - |
pH 7.5, isozyme hGIIA sPLA2 | Homo sapiens | 3-[4-[3-(pentyloxy)-2-(tetradecyloxy)propoxy]benzyl]-1,2,4-oxadiazol-5(4H)-one | |
0.01 | - |
pH 7.5, isozyme hGIB sPLA2 | Homo sapiens | 3-[4-[3-(decyloxy)-2-(tetradecyloxy)propoxy]benzyl]-1,2,4-oxadiazol-5(4H)-one | |
0.012 | - |
pH 7.5, isozyme hGX sPLA2 | Homo sapiens | 3-[4-[3-(4-butylphenoxy)-2-(tetradecyloxy)propoxy]benzyl]-1,2,4-oxadiazol-5(4H)-one | |
0.014 | - |
pH 7.5, isozyme hGX sPLA2 | Homo sapiens | 3-[4-[3-(4-methylphenoxy)-2-(tetradecyloxy)propoxy]benzyl]-1,2,4-oxadiazol-5(4H)-one | |
0.0148 | - |
pH 7.5, isozyme hGIIA sPLA2 | Homo sapiens | 3-[4-[3-(4-methylphenoxy)-2-(tetradecyloxy)propoxy]benzyl]-1,2,4-oxadiazol-5(4H)-one | |
0.015 | - |
pH 7.5, isozyme hGIB sPLA2 | Homo sapiens | 3-[4-[3-(4-butylphenoxy)-2-(tetradecyloxy)propoxy]benzyl]-1,2,4-oxadiazol-5(4H)-one | |
0.018 | - |
pH 7.5, isozyme hGIB sPLA2 | Homo sapiens | 3-[4-[3-(diphenylmethoxy)-2-(tetradecyloxy)propoxy]benzyl]-1,2,4-oxadiazol-5(4H)-one | |
0.021 | - |
pH 7.5, isozyme hGIIA sPLA2 | Homo sapiens | 3,3'-[[3-(tetradecyloxy)propane-1,2-diyl]bis(oxybenzene-4,1-diylmethanediyl)]bis(1,2,4-oxadiazol-5(4H)-one) | |
0.022 | - |
pH 7.5, isozyme hGV sPLA2 | Homo sapiens | 3-[4-[3-(4-butylphenoxy)-2-(tetradecyloxy)propoxy]benzyl]-1,2,4-oxadiazol-5(4H)-one | |
0.025 | - |
pH 7.5, isozyme hGIB sPLA2 | Sus scrofa | 3-[4-[3-(4-methylphenoxy)-2-(tetradecyloxy)propoxy]benzyl]-1,2,4-oxadiazol-5(4H)-one | |
0.0298 | - |
pH 7.5, isozyme hGIIA sPLA2 | Homo sapiens | 3-[4-[3-ethoxy-2-(tetradecyloxy)propoxy]benzyl]-1,2,4-oxadiazol-5(4H)-one | |
0.0305 | - |
above, pH 7.5, isozyme hGIIA sPLA2 | Homo sapiens | 3,3'-[[2-(pentyloxy)propane-1,3-diyl]bis(oxybenzene-4,1-diylethane-2,1-diyl)]bis(1,2,4-oxadiazol-5(4H)-one) | |
0.0399 | - |
pH 7.5, isozyme hGIB sPLA2 | Sus scrofa | 3,3'-[[2-(tetradecyloxy)propane-1,3-diyl]bis(oxybenzene-4,1-diylethane-2,1-diyl)]bis(1,2,4-oxadiazol-5(4H)-one) | |
0.04 | - |
pH 7.5, isozyme hGIB sPLA2 | Sus scrofa | 3-[4-[3-ethoxy-2-(tetradecyloxy)propoxy]benzyl]-1,2,4-oxadiazol-5(4H)-one | |
0.0477 | - |
above, pH 7.5, isozyme hGIIA sPLA2 | Homo sapiens | 3,3'-[[2-(tetradecyloxy)propane-1,3-diyl]bis(oxybenzene-4,1-diylmethanediyl)]bis(1,2,4-oxadiazol-5(4H)-one) | |
0.05 | - |
pH 7.5, isozyme hGIB sPLA2 | Sus scrofa | 3-O-[4-(4,5-dihydro-5-oxo-1,2,4-4H-oxadiazol-3-yl)phenyl]-2-O-tetradecyl-1-O-triphenylmethylglycerol | |
0.0578 | - |
pH 7.5, isozyme hGIB sPLA2 | Sus scrofa | 3,3'-[[3-(tetradecyloxy)propane-1,2-diyl]bis(oxybenzene-4,1-diylethane-2,1-diyl)]bis(1,2,4-oxadiazol-5(4H)-one) | |
0.0636 | - |
pH 7.5, isozyme hGIB sPLA2 | Sus scrofa | 3,3'-[[3-(tetradecyloxy)propane-1,2-diyl]bis(oxybenzene-4,1-diylmethanediyl)]bis(1,2,4-oxadiazol-5(4H)-one) | |
0.1 | - |
above, pH 7.5, isozyme hGIB sPLA2 | Sus scrofa | 3,3'-[[2-(tetradecyloxy)propane-1,3-diyl]bis(oxybenzene-4,1-diylmethanediyl)]bis(1,2,4-oxadiazol-5(4H)-one) | |
0.1 | - |
above, pH 7.5, isozyme hGIB sPLA2 | Sus scrofa | 3,3'-[[2-(pentyloxy)propane-1,3-diyl]bis(oxybenzene-4,1-diylethane-2,1-diyl)]bis(1,2,4-oxadiazol-5(4H)-one) | |
0.1 | - |
pH 7.5, isozyme hGIB sPLA2 | Sus scrofa | 3-[4-[3-(decyloxy)-2-(tetradecyloxy)propoxy]benzyl]-1,2,4-oxadiazol-5(4H)-one | |
0.1 | - |
pH 7.5, isozyme hGIB sPLA2 | Homo sapiens | 3-[4-[3-(4-methylphenoxy)-2-(tetradecyloxy)propoxy]benzyl]-1,2,4-oxadiazol-5(4H)-one | |
0.1 | - |
pH 7.5, isozyme hGIB sPLA2 | Sus scrofa | 3-[4-[3-(pentyloxy)-2-(tetradecyloxy)propoxy]benzyl]-1,2,4-oxadiazol-5(4H)-one | |
0.1 | - |
pH 7.5, isozyme hGV sPLA2 | Homo sapiens | 3-[4-[3-(4-methylphenoxy)-2-(tetradecyloxy)propoxy]benzyl]-1,2,4-oxadiazol-5(4H)-one |