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Literature summary for 3.1.1.4 extracted from

  • Grkovich, A.; Armando, A.; Quehenberger, O.; Dennis, E.A.
    TLR-4 mediated group IVA phospholipase A2 activation is phosphatidic acid phosphohydrolase 1 and protein kinase C dependent (2009), Biochim. Biophys. Acta, 1791, 975-982.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.1.4

Activating Compound

Activating Compound Comment Organism Structure
ATP cellular GIVA PLA2 activity is induced by the treatment of cells with Ca+2 mobilizing agonists, such as the purinergic P2X7 receptor agonist ATP Mus musculus
diacylglycerol exogenous diacylglycerol stimulates GIVA PLA2-mediated arachidonic acid release Mus musculus
additional information involvement of phosphatidic acid phosphohydrolase 1 (PAP-1) and protein kinase C (PKC) in the Toll-like receptor-4 (TLR-4) activation of GIVA PLA2. Ca+2 influx is not required for TLR-4 mediated activation of the GIVA PLA2 Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
additional information neither PAP-1 nor PKC inhibition reduces GIVA PLA2 synergistic activation by stimulation with Kdo2-Lipid A and ATP. Neither EDTA nor EGTA reduce the arachidonic acid release Mus musculus
pyrrophenone pretreatment of cells with pyrrophenone reduces Kdo2-lipid A stimulated arachidonic acid release to background levels Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
macrophage
-
 Mus musculus
-
RAW-264.7 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glycerophospholipid + H2O
-
 Mus musculus arachidonic acid + ?
-
 ?

Synonyms

Synonyms Comment Organism
GIVA PLA2
-
 Mus musculus
group IVA phospholipase A2
-
 Mus musculus