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Literature summary for 3.1.1.4 extracted from

  • Murakami, M.T.; Kuch, U.; Betzel, C.; Mebs, D.; Arni, R.K.
    Crystal structure of a novel myotoxic Arg49 phospholipase A2 homolog (zhaoermiatoxin) from Zhaoermia mangshanensis snake venom: insights into Arg49 coordination and the role of Lys122 in the polarization of the C-terminus (2008), Toxicon, 51, 723-735.
    View publication on PubMed
Search for more literature for 3.1.1.4

Crystallization (Commentary)

Crystallization (Comment) Organism
mutant K49R, X-ray diffraction structure determination and analysis at 2.05 A resolution, molecular replacement technique Protobothrops mangshanensis

Protein Variants

Protein Variants Comment Organism
K49R catalytically inactive enzyme, the orientation of the Arg49 side chain results in a similar binding mode to that observed in the Lys49 PLA2s Protobothrops mangshanensis

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Protobothrops mangshanensis
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ binding site structure analysis, overview Protobothrops mangshanensis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
13972
-
 x * 13972, amino acid sequence calculation Protobothrops mangshanensis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Protobothrops mangshanensis zhaoermiatoxin is highly myotoxic and displays high myonecrotic and edema activities ?
-
 ?

Organism

Organism UniProt Comment Textmining
Protobothrops mangshanensis P84776
-
-

Source Tissue

Source Tissue Comment Organism Textmining
venom
-
 Protobothrops mangshanensis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information zhaoermiatoxin is highly myotoxic and displays high myonecrotic and edema activities Protobothrops mangshanensis ?
-
 ?
additional information PEG 400 molecule binding structure, determination and analysis, overview Protobothrops mangshanensis ?
-
 ?

Subunits

Subunits Comment Organism
? x * 13972, amino acid sequence calculation Protobothrops mangshanensis
More structure molecular modelling Protobothrops mangshanensis

Synonyms

Synonyms Comment Organism
More the toxin is a group II phospholipase A2 Protobothrops mangshanensis
zhaoermiatoxin
-
 Protobothrops mangshanensis