Literature summary for 3.1.1.4 extracted from

Ma, L.; Uchida, H.; Nagai, J.; Inoue, M.; Aoki, J.; Ueda, H.
Evidence for de novo synthesis of lysophosphatidic acid in the spinal cord through phospholipase A2 and autotaxin in nerve injury-induced neuropathic pain (2010), J. Pharmacol. Exp. Ther., 333, 540-546.

Search for more literature for 3.1.1.4

Application

Application	Comment	Organism
drug development	targeted inhibition of PLA2- and autotaxin-mediated lysophosphatidic acid synthesis may be a potential strategy for the prevention of nerve injury-induced neuropathic pain	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
arachidonyl trifluoromethyl ketone	AACOCF3, both de novo lysophosphatidic acid production and neuropathic pain-like behaviors are substantially abolished by intrathecal injection of arachidonyl trifluoromethyl ketone, a mixed inhibitor of cPLA2 and iPLA2, at 1 h after injury	Mus musculus
bromoenol lactone	both de novo lysophosphatidic acid production and neuropathic pain-like behaviors are substantially abolished by intrathecal injection of bromoenol lactone, an iPLA2 inhibitor, at 1 h after injury	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	male C57BL/6J mice	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
spinal cord	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
arachidonyl thio-PC + H2O	-	Mus musculus	arachidonic acid + (7R)-4-hydroxy-N,N,N-trimethyl-7-sulfanyl-3,5,9-trioxa-4-phosphapentacosan-1-aminium 4-oxide	-	?

Synonyms

Synonyms	Comment	Organism
calcium-independent phospholipase A2	-	Mus musculus
cPLA2	-	Mus musculus
cytosolic phospholipase A2	-	Mus musculus
iPLA2	-	Mus musculus

General Information

General Information	Comment	Organism
physiological function	PLA2- and autotaxin-mediated de novo lysophosphatidic acid production in the early phase is involved in nerve injury-induced neuropathic pain	Mus musculus

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Release 2023.1 (January 2023)