Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | activity of the GVIA PLA2 may be regulated through many different mechanisms, including ATP binding, caspase cleavage, calmodulin, and possible ankyrin repeat mediated protein aggregation | Homo sapiens |
Application | Comment | Organism |
---|---|---|
drug development | with the classification of GVIIA PLA2 as a positive risk factor in coronary heart disease, it has become a very attractive drug target. Recent clinical trials with GVIIA PLA2 inhibitor have shown a decrease in the complex atherosclerotic lesions that lead to unstable lesions, as well as other cardiovascular disease markers | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
GIVA PLA2 and GVIIA PLA2 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
bromoenollactone | is not specific for GVIA PLA2 and actually functions through activation of the inhibitor by GVIA PLA2 followed by nonspecific covalent modification of cysteine residues in all proximally located enzymes | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | GIVA PLA2 | Homo sapiens | 5829 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
additional information | GIVA PLA2 does not require Ca2+ for catalytic activity | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Apis mellifera | - |
- |
- |
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Naja naja | - |
- |
- |
Purification (Comment) | Organism |
---|---|
GVIA PLA2 | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood platelet | GIVA PLA2 | Homo sapiens | - |
macrophage | GIVA PLA2 and GVIA PLA2 | Homo sapiens | - |
additional information | synovial fluid, GIIA PLA2 | Homo sapiens | - |
plasma | GVIIA PLA2 | Homo sapiens | - |
venom | group IA PLA2 | Naja naja | - |
venom | group III PLA2 | Apis mellifera | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | active splice forms of the enzyme GIVA-1 PLA2 and GIVA-2 PLA2 are composed of 7-8 ankyrin repeats, a linker region and a catalytic domain, uses a serine in the active site to catalyze the cleavage of the sn-2 ester bond | Homo sapiens | ? | - |
? | |
additional information | group IA enzyme appears to bind lipid substrate in the active site through the hydrophobic residues lining the active site channel, and binds neutral membrane substrate through interactions with a group of hydrophobic residues on the lipid binding surface of the molecule | Naja naja | ? | - |
? | |
additional information | similar activity to phospholipids with different fatty acids in the sn-2 position, but with different preferences for the charge on the lipid surface | Apis mellifera | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Ca2+ independent PLA2 | group VIA PLA2 | Homo sapiens |
cytosolic calcium-dependent PLA2 | GIVA PLA2 | Homo sapiens |
GIIA PLA2 | - |
Homo sapiens |
GIVA PLA2 | - |
Mus musculus |
GIVA PLA2 | cytosolic calcium-dependent PLA2 | Homo sapiens |
group IA PLA2 | - |
Naja naja |
group IIA PLA2 | - |
Homo sapiens |
group III PLA2 | - |
Apis mellifera |
group IVA PLA2 | cytosolic calcium-dependent PLA2 | Homo sapiens |
Group VIA PLA2 | - |
Homo sapiens |
GVIA PLA2 | - |
Mus musculus |
GVIA PLA2 | - |
Homo sapiens |
GVIIA PLA2 | PAF acetyl hydrolase/oxidized lipid LpPLA2 | Homo sapiens |
PAF acetyl hydrolase/oxidized lipid LpPLA2 | - |
Homo sapiens |
phospholipase A2 | - |
Mus musculus |
phospholipase A2 | - |
Homo sapiens |
phospholipase A2 | - |
Apis mellifera |
phospholipase A2 | - |
Naja naja |
platelet activating factor acetyl hydrolase/oxidized lipid LpPLA2 | GVIIA PLA2 | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | absence of the GIVA PLA2 gene significantly reduces the effects of many inflammatory disease | Mus musculus |
malfunction | patient with defects in GIVA PLA2 shows decreases in PLA2 activity, eicosanoid biosynthesis, and the generation of many small intestinal ulcers | Homo sapiens |
physiological function | GIIA PLA2 is a potent antimicrobial agent. Role of the GVIA PLA2 in different signaling pathways. GVIIA PLA2 has anti-inflammatory activity in vivo, is a positive risk factor in coronary heart disease | Homo sapiens |
physiological function | GVIA PLA2 plays an important role in bone formation, apoptosis, insulin secretion, and sperm development. GVIA PLA2 in combination with the GIVA PLA2 play an important role in Wallerian degeneration and axon regeneration in nerve injury. GIVA PLA2 is generally considered to be a central enzyme mediating generation of eicosanoids and hence many inflammatory processes | Mus musculus |