Literature summary for 3.1.1.4 extracted from

Korotaeva, A.A.; Samoilova, E.V.; Piksina, G.F.; Prokazova, N.V.
Oxidized phosphatidylcholine stimulates activity of secretory phospholipase A2 group IIA and abolishes sphingomyelin-induced inhibition of the enzyme (2010), Prostaglandins Other Lipid Mediat., 91, 38-41.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	free L-alpha-dipalmitoyl phosphatidylcholine (in liposomes) and low density lipoprotein-incorporated L-alpha-dipalmitoyl phosphatidylcholine have no effect on the enzyme activity	Homo sapiens
oxidized palmitoyl arachidonyl phosphatidylcholine	either added to the assay medium as separated liposomes or incorporated in varied amounts into low density lipoprotein progressively enhances the activity of purified sPLA2(IIA)	Homo sapiens

Application

Application	Comment	Organism
drug development	influence on regulation of sPLA2(IIA) activity can be useful in the development of new therapeutic approaches to the treatment of cardiovascular diseases	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
sphingomyelin	suppresses the activating effect of oxidized palmitoyl arachidonyl phosphatidylcholine in a dose-dependent manner, abolishing it almost completely at a concentration 8times as high as that of oxidized palmitoyl arachidonyl phosphatidylcholine. Oxidized palmitoyl arachidonyl phosphatidylcholine completely abolishes the inhibitory effect of low density lipoprotein-incorporated sphingomyelin on the enzyme activity at the oxidized palmitoyl arachidonyl phosphatidylcholine/sphingomyelin concentration ratio 1:2	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
additional information	cardiac myxoma	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-alpha-dipalmitoyl phosphatidylcholine + H2O	-	Homo sapiens	1-palmitoyl-sn-glycerophosphocholine + palmitate	-	?
oxidized palmitoyl arachidonyl phosphatidylcholine + H2O	-	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
secretory phospholipase A2 group IIA	-	Homo sapiens
sPLA2(IIA)	-	Homo sapiens

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Release 2023.1 (January 2023)