Inhibitors | Comment | Organism | Structure |
---|---|---|---|
methyl arachidonyl fluorophosphonate | induces hepatitis C viral replication deficiency, not reversible by arachidonic acid in vivo | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | the enzyme colocalizes with NS4B and HCV replication complexes | Homo sapiens | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphatidylcholine + H2O | Homo sapiens | - |
1-acylglycerophosphocholine + a carboxylate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Lunet-Con1 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphatidylcholine + H2O | - |
Homo sapiens | 1-acylglycerophosphocholine + a carboxylate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
phospholipase A2 gamma | - |
Homo sapiens |
PLA2G4C | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | knockdown of the enzyme in hepatitis C virus-infected cells or hepatitis C virus replicon-containing cells by small interfering RNA significantly suppresses hepatitis C virus replication and assembly, not the viral entry, overview. In addition, the chemical inhibitor methyl arachidonyl fluorophosphonate, which specifically inhibits phospholipase A2, reduces hepatitis C virus replication and assembly. The membranous web structure formation is defective | Homo sapiens |
physiological function | the cytosolic phospholipase A2 gamma contributes to membranous web formation, hepatitis C virus replication, and assembly. The PLA2G4C gene is identified as a host gene with upregulated expression upon hepatitis C virus infection. The enzyme colocalizes with the hepatitis C virus proteins NS4B and NS5A in cells infected with JFH-1 and interacts with NS4B. In addition, the enzyme is able to transport the hepatitis C virus nonstructural proteins from replication sites to lipid droplets, the site for hepatitis C virus assembly | Homo sapiens |