Activating Compound | Comment | Organism | Structure |
---|---|---|---|
dithiothreitol | slightly acivating | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | 18% inhibition at 10 mM | Rattus norvegicus | |
DTNB | 69% inhibition at 2 mM | Rattus norvegicus | |
lyso-2-hexadecyl-1-alkyl-sn-glycero-3-phosphocholine | 22% inhibition at 0.05 mM | Rattus norvegicus | |
additional information | no inhibition by EGTA at 10 mM and acetylsalicylic acid at 0.2 mM | Rattus norvegicus | |
phosphocholine | 25% inhibition at 0.05 mM | Rattus norvegicus | |
PMSF | 93% inhibition at 2 mM | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0049 | - |
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine | pH 7.2, 37°C | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | adipocyte | Rattus norvegicus | 5829 | - |
additional information | activity in subcellular fractions | Rattus norvegicus | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
37000 | - |
x * 66000, major part, + x * 37000, mino part, SDS-PAGE | Rattus norvegicus |
66000 | - |
x * 66000, major part, + x * 37000, mino part, SDS-PAGE | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-hexadecyl-1-alkyl-sn-glycero-3-phosphocholine + H2O | Rattus norvegicus | i.e. platelet-activation factor, substrate and enzyme play important roles in inflammation processes | 1-hexadecyl-sn-glycero-3-phosphocholine + acetate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
male Wistar rats | - |
Purification (Comment) | Organism |
---|---|
from adipocyte, 45.9fold | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adipocyte | - |
Rattus norvegicus | - |
epididymis | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.02 | - |
partially purified enzyme | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O | - |
Rattus norvegicus | 1-alkyl-sn-glycero-3-phosphocholine + acetate | - |
? | |
2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine + H2O | i.e. platelet-activation factor | Rattus norvegicus | 1-hexadecyl-sn-glycero-3-phosphocholine + acetate | - |
? | |
2-hexadecyl-1-alkyl-sn-glycero-3-phosphocholine + H2O | i.e. platelet-activation factor, substrate and enzyme play important roles in inflammation processes | Rattus norvegicus | 1-hexadecyl-sn-glycero-3-phosphocholine + acetate | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 66000, major part, + x * 37000, mino part, SDS-PAGE | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
PAF-AH | - |
Rattus norvegicus |
platelet activating factor acetylhydrolase | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
30 min, stable | Rattus norvegicus |
60 | - |
10 min, almost complete inactivation | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
broad optimum | Rattus norvegicus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
5 | 7.4 | inactivation below pH 5.0, active to mild alkaline range | Rattus norvegicus |