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Literature summary for 3.1.1.47 extracted from
- Purification and characterization of 45 kDa PAF acetylhydrolase from bovine colostrum (2007), Biol. Pharm. Bull., 30, 1668-1673.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| iodoacetamide | - |
Bos taurus |  |
| additional information | no inactivation by NaF or dithiothreitol | Bos taurus | |
| p-bromophenacylbromide | - |
Bos taurus | |
| phenylmethylsulfonyl fluoride | - |
Bos taurus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0876 | - |
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine | - |
Bos taurus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 45000 | - |
1 * 45000, SDS-PAGE | Bos taurus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | Q29460 and P68401 | gamma-subunit and beta-subunit | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| colostrum | the greatest PAF-AH activity is detected on the day of parturition (day 0), after which its activity dramatically decreases and by day 5, the enzyme activity is less than 7% of the level at parturition | Bos taurus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.015 | - |
- |
Bos taurus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O | - |
Bos taurus | 1-O-alkyl-sn-glycero-3-phosphocholine + acetate | - |
? | |
| additional information | selectively hydrolyzes oxidatively modified phosphatidylcholine. The purified enzyme does not degrade phospholipids with a long chain fatty acyl group at the sn-2 position | Bos taurus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | 1 * 45000, SDS-PAGE | Bos taurus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetylhydrolase | - |
Bos taurus |
| PAF acetylhydrolase | - |
Bos taurus |
| PAF-AH | - |
Bos taurus |
| platelet activating factor acetylhydrolase | - |
Bos taurus |
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Release 2023.1 (January 2023)
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