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Literature summary for 3.1.1.53 extracted from
- Genomic and biochemical characterization of sialic acid acetylesterase (siae) in zebrafish (2017), Glycobiology, 27, 938-946 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in COS-7 cells | Danio rerio |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.129 | - |
4-nitrophenyl acetate | at pH 8.7 and 25°C | Danio rerio |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endoplasmic reticulum | - |
Danio rerio | 5783 | - |
| Golgi apparatus | - |
Danio rerio | 5794 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| sialic acid + H2O | Danio rerio | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Danio rerio | Q1LUX8 | - |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | - |
Danio rerio |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Danio rerio | - |
| central nervous system | - |
Danio rerio | - |
| eye | - |
Danio rerio | - |
| heart | - |
Danio rerio | - |
| kidney | - |
Danio rerio | - |
| liver | - |
Danio rerio | - |
| muscle | - |
Danio rerio | - |
| ovary | - |
Danio rerio | - |
| pronephric duct | - |
Danio rerio | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-nitrophenyl acetate + H2O | - |
Danio rerio | 4-nitrophenol + acetate | - |
? | |
| sialic acid + H2O | - |
Danio rerio | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 55000, SDS-PAGE | Danio rerio |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SIAE | - |
Danio rerio |
| sialic acid acetylesterase | - |
Danio rerio |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
- |
Danio rerio |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.7 | - |
- |
Danio rerio |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | 9 | below pH 5.7 enzymatic activity is almost negligible. By increasing the pH from pH 7.5 to alkaline values, enzyme activity reaches its maximum value at pH 8.7, followed by a drastic decrease at pH 9.0 with a residual activity of 32.8% | Danio rerio |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Danio rerio | the enzyme transcript is always detectable during development, with a more specific expression in the central nervous system, in pronephric ducts and liver in the more advanced stages of the embryo development | up |
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