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Literature summary for 3.1.1.53 extracted from
- Molecular cloning and characterization of lysosomal sialic acid O-acetylesterase (1996), J. Biol. Chem., 271, 13697-13705.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in COS-7 cells, both the larger and smaller Lse subunit | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Diethyl-4-nitrophenylphosphate | - |
Mus musculus |  |
| Diethyl-4-nitrophenylphosphate | - |
Rattus norvegicus | |
| diisopropyl fluorophosphate | - |
Mus musculus | |
| diisopropyl fluorophosphate | - |
Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 75000 | - |
x * 75000, nonreducing SDS-PAGE | Mus musculus |
| 250000 | - |
nonreducing PAGE, equal MW for both the larger and smaller Lse subunit, expressed in COS-7 cells | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | P70665 | - |
- |
| Rattus norvegicus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| side-chain modification | - |
Rattus norvegicus |
| side-chain modification | glycoprotein, Lse | Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| FDCP-Mix cl.A4 cell | hepatoietic cell line | Mus musculus | - |
| liver | - |
Rattus norvegicus | - |
| liver | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N-acetyl-9-O-acetylneuraminate + H2O | - |
Rattus norvegicus | N-acetylneuraminate + acetate | - |
? | |
| N-acetyl-9-O-acetylneuraminate + H2O | - |
Mus musculus | N-acetylneuraminate + acetate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | - |
Rattus norvegicus |
| ? | x * 75000, nonreducing SDS-PAGE | Mus musculus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Lse | - |
Rattus norvegicus |
| Lse | - |
Mus musculus |
| lysosomal sialic acid O-acetylesterase | - |
Rattus norvegicus |
| lysosomal sialic acid O-acetylesterase | - |
Mus musculus |
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