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Literature summary for 3.1.1.67 extracted from
- Purification to homogeneity and characterization of major fatty acid ethyl ester synthase from human myocardium (1989), FEBS Lett., 258, 236-239.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.12 | - |
stearate | pH 7.2 | Homo sapiens |  |
| 0.13 | - |
arachidonate | pH 7.2 | Homo sapiens | |
| 0.18 | - |
palmitate | pH 7.2 | Homo sapiens | |
| 0.2 | - |
linoleate | pH 7.2 | Homo sapiens | |
| 0.22 | 0.23 | oleate | pH 7.2 | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
| soluble | - |
Homo sapiens | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 26000 | - |
2 * 26000, SDS-PAGE | Homo sapiens |
| 54000 | - |
gel filtration under nondenaturing conditions | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| fatty acid + ethanol | Homo sapiens | nonoxidative ethanol metabolism | fatty acyl ethyl ester + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| 8867fold, major enzyme form, synthase I | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| heart | ventricular myocardium | Homo sapiens | - |
| myocardium | ventricular | Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Homo sapiens |
| 0.04433 | - |
major enzyme form | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| arachidonate + ethanol | 50% of the rate with oleate | Homo sapiens | ethyl arachidonate + H2O | - |
? | |
| fatty acid + ethanol | - |
Homo sapiens | fatty acyl ethyl ester + H2O | - |
? | |
| fatty acid + ethanol | nonoxidative ethanol metabolism | Homo sapiens | fatty acyl ethyl ester + H2O | - |
? | |
| linoleate + ethanol | 65% of the rate with oleate | Homo sapiens | ethyl linoleate + H2O | - |
? | |
| oleate + ethanol | highest activity | Homo sapiens | ethyl oleate + H2O | - |
? | |
| palmitate + ethanol | 20% of the rate with oleate | Homo sapiens | ethyl palmitate + H2O | - |
? | |
| stearate + ethanol | 22% of the rate with oleate | Homo sapiens | ethyl stearate + H2O | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 26000, SDS-PAGE | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.2 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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