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Literature summary for 3.1.1.79 extracted from
- Structure-function relationships of hormone-sensitive lipase (2001), Eur. J. Biochem., 268, 1899-1907.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in COS and insect cells | Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | HSL can translocate from the cytosol to the lipid droplet surface upom protein kinase phosphorylation | Rattus norvegicus | 5829 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 84032 | - |
x * 84032, deduced from nucleotide sequence | Homo sapiens |
| 84073 | - |
x * 84073, deduced from nucleotide sequence, HSL might be a homodimer in solution | Rattus norvegicus |
| 116000 | - |
x * 116000, SDS-PAGE, testis HSL | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cholesteryl ester + H2O | Mus musculus | - |
cholesterol + a carboxylate | - |
? |  |
| diacylglycerol + H2O | Rattus norvegicus | - |
monoacylglycerol + a carboxylate | - |
? | |
| monoacylglycerol + H2O | Rattus norvegicus | - |
glycerol + a carboxylate | - |
? | |
| triacylglycerol + H2O | Rattus norvegicus | - |
diacylglycerol + a carboxylate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | - |
Homo sapiens |
| phosphoprotein | phosphorylation sites at S563 and S565 | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adipose tissue | - |
Mus musculus | - |
| adipose tissue | - |
Homo sapiens | - |
| adipose tissue | - |
Rattus norvegicus | - |
| brown adipose tissue | - |
Mus musculus | - |
| testis | - |
Mus musculus | - |
| testis | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 100 | - |
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1,2-dioleoyl-sn-glycerol + H2O | - |
Homo sapiens | 2-oleylglycerol + oleate | - |
? | |
| 1,2-dioleoyl-sn-glycerol + H2O | - |
Rattus norvegicus | 2-oleylglycerol + oleate | - |
? | |
| cholesteryl ester + H2O | - |
Mus musculus | cholesterol + a carboxylate | - |
? | |
| cholesteryl oleate + H2O | - |
Homo sapiens | cholesterol + oleate | - |
? | |
| cholesteryl oleate + H2O | - |
Rattus norvegicus | cholesterol + oleate | - |
? | |
| diacylglycerol + H2O | - |
Rattus norvegicus | monoacylglycerol + a carboxylate | - |
? | |
| monoacylglycerol + H2O | - |
Rattus norvegicus | glycerol + a carboxylate | - |
? | |
| p-nitrophenyl butyrate + H2O | - |
Homo sapiens | p-nitrophenol + butanoate | - |
? | |
| p-nitrophenyl butyrate + H2O | - |
Rattus norvegicus | p-nitrophenol + butanoate | - |
? | |
| triacylglycerol + H2O | - |
Rattus norvegicus | diacylglycerol + a carboxylate | - |
? | |
| tributanoylglycerol + H2O | - |
Homo sapiens | dibutanoylglycerol + butanoate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 116000, SDS-PAGE, testis HSL | Homo sapiens |
| ? | x * 84032, deduced from nucleotide sequence | Homo sapiens |
| dimer | x * 84073, deduced from nucleotide sequence, HSL might be a homodimer in solution | Rattus norvegicus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HSL | - |
Mus musculus |
| HSL | - |
Homo sapiens |
| HSL | - |
Rattus norvegicus |
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