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Literature summary for 3.1.2.18 extracted from

  • Alexson, S.E.H.; Nedergard, J.
    A novel type of short- and medium-chain acyl-CoA hydrolases in brown adipose tissue mitochondria (1988), J. Biol. Chem., 263, 13564-13571.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information cold acclimation induces enzyme activity Mesocricetus auratus
additional information no activation by ATP or AMP Mesocricetus auratus

General Stability

General Stability Organism
ADP stabilizes Mesocricetus auratus

Inhibitors

Inhibitors Comment Organism Structure
AMP inhibitory at high concentration Mesocricetus auratus
ATP inhibitory at high concentration Mesocricetus auratus
beta-NADH stereospecific: not alpha-NADH, reversible by ADP or Ca2+, not by Mg2+ Mesocricetus auratus
Cd2+
-
Mesocricetus auratus
additional information no inhibition by alpha-NADH, NADPH, NAD+, EDTA or EGTA Mesocricetus auratus
Ni2+
-
Mesocricetus auratus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.013
-
ADP pH 7.4, 25°C Mesocricetus auratus
0.3
-
Ca2+ pH 7.4, 25°C Mesocricetus auratus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial matrix submitochondrial distribution Mesocricetus auratus 5759
-
mitochondrion
-
Mesocricetus auratus 5739
-
additional information submitochondrial and subcellular distribution Mesocricetus auratus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ activation, Km-value: 0.3 mM Mesocricetus auratus
K+ activation Mesocricetus auratus
Mg2+ activation Mesocricetus auratus
additional information no activation by Na+ Mesocricetus auratus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acyl-CoA + H2O Mesocricetus auratus
-
CoA + a carboxylate
-
?

Organism

Organism UniProt Comment Textmining
Mesocricetus auratus
-
Syrian hamster, adult female, acclimated to cold
-

Source Tissue

Source Tissue Comment Organism Textmining
brown adipose tissue
-
Mesocricetus auratus
-
additional information not in liver tissue Mesocricetus auratus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-CoA + H2O
-
Mesocricetus auratus CoA + a carboxylate
-
?
malonyl-CoA + H2O very poor substrate Mesocricetus auratus malonate + CoA
-
?
propionyl-CoA + H2O best substrate Mesocricetus auratus CoA + propionate
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Mesocricetus auratus

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
25
-
t1/2: 1 min, in buffer with Triton X-100 but without substrates, decrease of activity in intact mitochondria, ADP stabilizes: t1/2: 1 h, substrates protect Mesocricetus auratus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Mesocricetus auratus

Cofactor

Cofactor Comment Organism Structure
ADP requirement Mesocricetus auratus