Activating Compound | Comment | Organism | Structure |
---|---|---|---|
PPARalpha | internal receptor protein essential for effect of stimulating compounds | Mus musculus | |
PPARalpha | i.e. peroxisome proliferator-activated receptor alpha | Mus musculus |
Cloned (Comment) | Organism |
---|---|
DNA sequence determination and analysis, expression in Escherichia coli BL21(DE3) | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
acyl-CoA | substrate inhibition at concentrations higher than 0.005-0.01 mM of acyl-CoA longer than C10, BSA protects | Mus musculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | - |
Mus musculus | |
0.0014 | - |
palmitoleoyl-CoA | pH 7.4 | Mus musculus | |
0.0017 | - |
hexadecanoyl-CoA | pH 7.4 | Mus musculus | |
0.0023 | - |
linoleoyl-CoA | pH 7.4 | Mus musculus | |
0.0025 | - |
tetradecanoyl-CoA | pH 7.4 | Mus musculus | |
0.0042 | - |
arachidoyl-CoA | pH 7.4 | Mus musculus | |
0.0067 | - |
Arachidonoyl-CoA | pH 7.4 | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
peroxisome | isozyme PTE-II | Mus musculus | 5777 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
4,8-dimethylnonanoyl-CoA + H2O | Mus musculus | - |
CoA + 4,8-dimethylnonanoate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P58137 | gene pte-2, isozyme PTE-II | - |
Purification (Comment) | Organism |
---|---|
recombinant from Escherichia coli | Mus musculus |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
an acyl-CoA + H2O = CoA + a carboxylate | catalytic triad D233-S255-Q305 | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | ubiquitous expression | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-methylstearoyl-CoA + H2O | - |
Mus musculus | CoA + 2-methylstearate | - |
? | |
2-trans-decenoyl-CoA + H2O | - |
Mus musculus | CoA + 2-trans-decenoate | - |
? | |
3-hydroxy-3-methyl glutaryl-CoA + H2O | - |
Mus musculus | CoA + 3-hydroxy-3-methyl glutarate | - |
? | |
3-hydroxyhexadecanoyl-CoA + H2O | - |
Mus musculus | CoA + 3-hydroxyhexadecanoate | - |
? | |
4,8-dimethylnonanoyl-CoA + H2O | - |
Mus musculus | CoA + 4,8-dimethylnonanoate | - |
? | |
acetoacetyl-CoA + H2O | - |
Mus musculus | CoA + acetoacetate | - |
? | |
acetyl-CoA + H2O | - |
Mus musculus | CoA + acetate | - |
? | |
acyl-CoA + H2O | long-chain fatty-acyl-CoA | Mus musculus | CoA + a carboxylate | - |
? | |
arachidonoyl-CoA + H2O | - |
Mus musculus | CoA + arachidonate | - |
? | |
arachidoyl-CoA + H2O | - |
Mus musculus | CoA + arachidate | - |
? | |
chenodeoxycholoyl-CoA + H2O | activity is PPARalpha-inducible | Mus musculus | CoA + chenodeoxycholoate | - |
? | |
chenodeoxycholoyl-CoA + H2O | bile acid derivative substrate | Mus musculus | CoA + chenodeoxycholoate | - |
? | |
choloyl-CoA + H2O | activity is PPARalpha-inducible | Mus musculus | CoA + choloate | - |
? | |
choloyl-CoA + H2O | bile acid derivative substrate | Mus musculus | CoA + choloate | - |
? | |
clofibroyl-CoA + H2O | - |
Mus musculus | CoA + clofibrate | - |
? | |
decanoyl-CoA + H2O | - |
Mus musculus | CoA + decanoate | - |
? | |
dodecanoyl-CoA + H2O | - |
Mus musculus | CoA + dodecanoate | - |
? | |
hexadecanoyl-CoA + H2O | - |
Mus musculus | CoA + hexadecanoate | - |
? | |
hexanoyl-CoA + H2O | - |
Mus musculus | CoA + hexanoate | - |
? | |
linoleoyl-CoA + H2O | - |
Mus musculus | CoA + linoleate | - |
? | |
malonyl-CoA + H2O | - |
Mus musculus | CoA + malonate | - |
? | |
myristoyl-CoA + H2O | - |
Mus musculus | CoA + myristate | - |
? | |
n-butyryl-CoA + H2O | - |
Mus musculus | CoA + n-butanoate | - |
? | |
octadecanoyl-CoA + H2O | - |
Mus musculus | CoA + octadecanoate | - |
? | |
octanoyl-CoA + H2O | - |
Mus musculus | CoA + octanoate | - |
? | |
oleoyl-CoA + H2O | - |
Mus musculus | CoA + oleate | - |
? | |
palmitoleoyl-CoA + H2O | - |
Mus musculus | CoA + palmitoleoate | - |
? | |
propionyl-CoA + H2O | - |
Mus musculus | CoA + propionate | - |
? | |
prostaglandin F2alpha-CoA + H2O | - |
Mus musculus | prostaglandin F2alpha + CoA | - |
? | |
tetradecanoyl-CoA + H2O | - |
Mus musculus | CoA + tetradecanoate | - |
? | |
trihydroxycoprostanoyl-CoA + H2O | - |
Mus musculus | CoA + trihydroxycoprostanoate | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Mus musculus |