Cloned (Comment) | Organism |
---|---|
DNA sequence determination and analysis of the single HAGH gene encoding both the cytosolic and mitochondrial isozymes, in vitro transcription, 2 splicing forms of mRNA | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
cytosol | cytosolic isozyme | Homo sapiens | 5829 | - |
mitochondrial matrix | mitochondrial isozyme is targeted directly to the mitochondrial matrix due to a mitochondrial targeting sequence | Homo sapiens | 5759 | - |
mitochondrion | - |
Homo sapiens | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-D-lactoylglutathione + H2O | Homo sapiens | - |
glutathione + D-lactate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
HAGH gene encodes both cytosolic and mitochondrial forms of glyoxalase II | - |
Homo sapiens | Q16775 | cytosolic and mitochondrial isozyme, both encoded by gene HAGH for hydroxyacylglutathione hydrolase | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | enzyme shows broad substrate specificity with a preference for 2-hydoxy thiol esters | Homo sapiens | ? | - |
? | |
S-D-lactoylglutathione + H2O | - |
Homo sapiens | glutathione + D-lactate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
acetoacetylglutathione hydrolase | - |
Homo sapiens |
Germ cell specific protein | - |
Homo sapiens |
GLO II | - |
Homo sapiens |
glyoxalase II | - |
Homo sapiens |
HAGH | - |
Homo sapiens |
hydrolase, acetoacetylglutathione | - |
Homo sapiens |
hydrolase, hydroxyacylglutathione | - |
Homo sapiens |
More | enzyme is a member of the zinc metallohydrolase family with a beta-lactamase fold | Homo sapiens |
Round spermatid protein RSP29 | - |
Homo sapiens |
S-2-hydroxylacylglutathione hydrolase | - |
Homo sapiens |