Literature summary for 3.1.21.7 extracted from

Prince, M.A.; Friedman, B.; Gruskin, E.A.; Schrock III, R.D.; Lloyd, R.S.
Selective metal binding to Cys-78 within endonuclease V cause an inhibition of catalytic aactivities without altering nontarget and target DNA binding (1991), J. Biol. Chem., 266, 10686-10693.

Search for more literature for 3.1.21.7

Cloned(Commentary)

Cloned (Comment)	Organism
-	Tequatrovirus T4

Protein Variants

Protein Variants	Comment	Organism
C78T	100 times more activity in the presence Hg2+ or Ag+ at concentrations they are required to inhibit the wild type enzyme	Tequatrovirus T4

Inhibitors

Inhibitors	Comment	Organism	Structure
Ag2+	50% inhibition at 0.01 mM	Tequatrovirus T4
Cu2+	50% inhibition at 0.025 mM	Tequatrovirus T4
Hg2+	50% inhibition at 0.0006 mM, inhibition of both DNA glycosylase and apurinic nicking activities, binding capability not reduced	Tequatrovirus T4

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
double-stranded plasmid DNA + H2O	Tequatrovirus T4	supercoiled pBR322-DNA	nicked circular DNA + linearized DNA	-	?

Organism

Organism	UniProt	Comment	Textmining
Tequatrovirus T4	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Tequatrovirus T4

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
double-stranded plasmid DNA + H2O	supercoiled pBR322-DNA	Tequatrovirus T4	nicked circular DNA + linearized DNA	-	?

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Release 2023.1 (January 2023)