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Literature summary for 3.1.26.3 extracted from

  • Lim, B.; Sim, S.H.; Sim, M.; Kim, K.; Jeon, C.O.; Lee, Y.; Ha, N.C.; Lee, K.
    RNase III controls the degradation of corA mRNA in Escherichia coli (2012), J. Bacteriol., 194, 2214-2220.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information construction of mutant strain MG1655rnc-14::DELTATn10 Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
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-
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Escherichia coli MG1655
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-
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Synonyms

Synonyms Comment Organism
RNase III
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Escherichia coli

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
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assay at Escherichia coli

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.9
-
assay at Escherichia coli

General Information

General Information Comment Organism
metabolism the RNase III-mediated regulatory pathway functions to modulate corA expression and, in turn, the influx of metal ions transported by CorA in Escherichia coli Escherichia coli
physiological function the steady-state levels of metal transporter corA mRNA as well as the degree of cobalt influx into the cell are dependent on cellular concentrations of the enzyme RNase III. Enzyme RNase III cleavage constitutes a rate-determining step for corA mRNA degradation, downregulation of corA expression by the enzyme, overview. Introduction of point mutations in RNase III cleavage sites C-122G, U-153A, and A-152G of corA mRNA abolishes the enzyme cleavage activity on corA mRNA and results in prolonged half-lives of the mRNA Escherichia coli