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Literature summary for 3.1.26.3 extracted from

  • Kavalchuk, K.; Madhusudan, S.; Schnetz, K.
    RNase III initiates rapid degradation of proU mRNA upon hypo-osmotic stress in Escherichia coli (2012), RNA Biol., 9, 98-109.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information enzyme activity is increased at low osmolarity Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
additional information enzyme activity is inhibited at high osmolarity Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Escherichia coli RNase III specifically processes the proU mRNA within a conserved secondary structure extending from position +203 to +293 of the transcript ?
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?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information RNase III specifically processes the proU mRNA within a conserved secondary structure extending from position +203 to +293 of the transcript Escherichia coli ?
-
?

Synonyms

Synonyms Comment Organism
RNase III
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Escherichia coli

General Information

General Information Comment Organism
malfunction blocking of RNase III processing by mutation of the processing site eliminates post-transcriptional osmoregulation of proU Escherichia coli
physiological function the enzyme RNase III initiates rapid degradation of proU mRNA upon hypoosmotic stress, osmoregulation occurs at a post-transcriptional level. Upon osmotic downshift, the enzyme immediately processes the proU mRNA which reduces its half-life from 65 sec to less than 4 sec Escherichia coli