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Literature summary for 3.1.26.3 extracted from
- RNase III is required for localization to the nucleoid of the 5 pre-rRNA leader and for optimal induction of rRNA synthesis in E. coli (2013), RNA, 19, 1200-1207.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | B1XB41 | MG1655, gene rnc | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the enzyme is active with DAPI-enriched pre-rRNA fragments | Escherichia coli | ? | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| RNase III | - |
Escherichia coli |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | gene rnc deletion mutants are slow in rRNA operon induction and synthetically lethal with gene fis, encoding the transcriptional regulator Fis. In the absence of RNase III, not only the double pre-rRNP length gradient is lost but also the relative RNA polymerase occupancy in the spacer and nonspacer regions are approximately similar | Escherichia coli |
| physiological function | the enzyme plays a role in the rapid induction of ribosomal operons during outgrowth and is essential in the absence of the transcriptional regulator Fis, suggesting a linkage of transcription and RNA processing for ribosomal operons in Escherichia coli, the enzyme has an effect on ribosome operon transcription and is involved in the early process steps of rRNA biogenesis, overview The enzyme is required for localization of the 5 pre-rRNA leader to the nucleoid and for optimal induction of rRNA synthesis. RNase III processing of pre-rRNA occurs cotranscriptionally | Escherichia coli |
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