Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.26.5 extracted from

  • Guerrier-Takada, C.; Eder, P.S.; Gopalan, V.; Altman, S.
    Purification and characterization of Rpp25, an RNA-binding protein subunit of human ribonuclease P (2002), RNA, 8, 290-295.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.26.5

Cloned(Commentary)

Cloned (Comment) Organism
expression of wild-type enzyme and protein subunit Rpp25 in Escherichia coli Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
tRNA precursor + H2O Homo sapiens enzyme is responsible for removing the 5'-leader segment of precursor tRNA during maturation mature tRNA + 5'-terminal oligonucleotide
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant protein subunit Rpp25, and native wild-type enzyme from HeLa cells Homo sapiens

Reaction

Reaction Comment Organism Reaction ID
endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor an RNA-containing enzyme, essential for tRNA processing, generates 5'-termini or mature tRNA molecules, the RNA subunit is the catalytic unit, while protein subunit Rpp25 is involved in RNA substrate binding, both interact with each other Homo sapiens
a

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
tRNA precursor + H2O cleavage of 5'-terminal oligonucleotide Homo sapiens mature tRNA + 5'-oligonucleotide generates 5'-phosphate,3'-hydroxyl-product ?
tRNA precursor + H2O enzyme is responsible for removing the 5'-leader segment of precursor tRNA during maturation Homo sapiens mature tRNA + 5'-terminal oligonucleotide
-
 ?

Subunits

Subunits Comment Organism
oligomer enzyme is composed of 1 RNA subunit H1 and at least 9 protein subunits, namely Rpp14, Rpp20, Rpp21, Rpp29 i.e. Pop4, Rpp30, Rpp40, Pop1, Pop5, and Rpp25 Homo sapiens

Synonyms

Synonyms Comment Organism
RNase P
-
 Homo sapiens
tRNA processing enzyme
-
 Homo sapiens