Literature summary for 3.1.26.5 extracted from

Kawamoto, S.A.; Sudhahar, C.G.; Hatfield, C.L.; Sun, J.; Behrman, E.J.; Gopalan, V.
Studies on the mechanism of inhibition of bacterial ribonuclease P by aminoglycoside derivatives (2008), Nucleic Acids Res., 36, 697-704.

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Inhibitors

Inhibitors	Comment	Organism	Structure
NeoG6	N,N'''-[(1R,3S,4R,5R,6S)-4-[(2,6-dicarbamimidamido-2,6-dideoxy-alpha-D-glucopyranosyl)oxy]-5-[[3-O-(2,6-dicarbamimidamido-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy]-6-hydroxycyclohexane-1,3-diyl]diguanidine	Escherichia coli
NeoK6	D-streptamine, O-2,6-dideoxy-2,6-bis[[(2S)-2,6-diamino-1-oxohexyl]amino]-beta-L-idopyranosyl-(1-3)-O-beta-D-ribofuranosyl-(1-5)-O-[2,6-dideoxy-2,6-bis[[(2S)-2,6-diamino-1-oxohexyl]amino]-alpha-D-glucopyranosyl-(1-4)]-2-deoxy-N1,N3-bis[(2S)-2,6-diamino-1-oxohexyl]-	Escherichia coli
neomycinB	-	Escherichia coli
NeoR5	D-streptamine, O-2,6-bis[[(2S)-2-amino-5-[(aminoiminomethyl)amino]-1-oxopentyl]amino]-2,6-dideoxy-beta-L-idopyranosyl-(1-3)-O-beta-D-ribofuranosyl-(1-5)-O-[2,6-bis[[(2S)-2-amino-5-[(aminoiminomethyl)amino]-1-oxopentyl]amino]-2,6-dideoxy-alpha-D-glucopyranosyl-(1-4)]-N1-[(2S)-2-amino-5-[(aminoiminomethyl)amino]-1-oxopentyl]-2-deoxy-	Escherichia coli
NeoR5	D-streptamine, O-2,6-bis[[(2S)-2-amino-5-[(aminoiminomethyl)amino]-1-oxopentyl]amino]-2,6-dideoxy-beta-L-idopyranosyl-(1-3)-O-beta-D-ribofuranosyl-(1-5)-O-[2,6-bis[[(2S)-2-amino-5-[(aminoiminomethyl)amino]-1-oxopentyl]amino]-2,6-dideoxy-alpha-D-glucopyranosyl-(1-4)]-N1-[(2S)-2-amino-5-[(aminoiminomethyl)amino]-1-oxopentyl]-2-deoxy- (NeoR5), Methanothermobacter thermautotrophicus RNase P is inhibited quite significantly and progressively up to 10 microM NeoR5	Methanothermobacter thermautotrophicus
NeoR5	NeoR5	Pyrococcus furiosus

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	-	Escherichia coli
Mg2+	-	Methanothermobacter thermautotrophicus
Mg2+	-	Pyrococcus furiosus
Mg2+	-	Methanocaldococcus jannaschii

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Escherichia coli	5'-maturation of transfer RNA	?	-	?
additional information	Methanothermobacter thermautotrophicus	5-maturation of transfer RNA	?	-	?
additional information	Pyrococcus furiosus	5-maturation of transfer RNA	?	-	?
additional information	Methanocaldococcus jannaschii	5-maturation of transfer RNA	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-
Methanocaldococcus jannaschii	-	-	-
Methanothermobacter thermautotrophicus	-	-	-
Pyrococcus furiosus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	5'-maturation of transfer RNA	Escherichia coli	?	-	?
additional information	5-maturation of transfer RNA	Methanothermobacter thermautotrophicus	?	-	?
additional information	5-maturation of transfer RNA	Pyrococcus furiosus	?	-	?
additional information	5-maturation of transfer RNA	Methanocaldococcus jannaschii	?	-	?

Synonyms

Synonyms	Comment	Organism
ribonuclease P	-	Escherichia coli
ribonuclease P	-	Methanothermobacter thermautotrophicus
ribonuclease P	-	Pyrococcus furiosus
ribonuclease P	-	Methanocaldococcus jannaschii
RNase P	-	Escherichia coli
RNase P	-	Methanothermobacter thermautotrophicus
RNase P	-	Pyrococcus furiosus
RNase P	-	Methanocaldococcus jannaschii

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0005	-	-	Escherichia coli	NeoR5
0.003	-	-	Escherichia coli	NeoK6
0.006	-	-	Escherichia coli	NeoG6
0.4	-	-	Escherichia coli	neomycinB

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Release 2023.1 (January 2023)