Literature summary for 3.1.26.5 extracted from

Ellis, J.; Brown, J.
The RNase P family (2009), RNA Biol., 6, 362-369.

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
chloroplast	-	Porphyra purpurea	9507	-
mitochondrion	-	Homo sapiens	5739	-
mitochondrion	-	Saccharomyces cerevisiae	5739	-
mitochondrion	-	Giardia intestinalis	5739	-
mitochondrion	-	Porphyra purpurea	5739	-
mitochondrion	-	Reclinomonas americana	5739	-
nucleus	-	Homo sapiens	5634	-
nucleus	-	Saccharomyces cerevisiae	5634	-
nucleus	-	Giardia intestinalis	5634	-
nucleus	-	Porphyra purpurea	5634	-
nucleus	-	Reclinomonas americana	5634	-

Organism

Organism	UniProt	Comment	Textmining
Bacillus subtilis	-	-	-
Chlamydia trachomatis	-	-	-
Chlorobium limicola	-	-	-
Cupriavidus necator	-	-	-
Escherichia coli	-	-	-
Giardia intestinalis	-	-	-
Homo sapiens	-	-	-
Methanocaldococcus jannaschii	-	-	-
Methanothermobacter thermautotrophicus	-	-	-
Mycoplasma hyopneumoniae	-	-	-
Mycoplasmopsis fermentans	-	-	-
no activity in Aquifex aeolicus	-	-	-
Porphyra purpurea	-	-	-
Pyrobaculum aerophilum	-	-	-
Reclinomonas americana	-	-	-
Saccharomyces cerevisiae	-	-	-
Synechococcus elongatus PCC 6301	-	-	-
Thermomicrobium roseum	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.
additional information	cleaves riboswitchs	Bacillus subtilis	?	-	?
additional information	cleaves riboswitchs	Escherichia coli	?	-	?
pre-tRNA + H2O	-	Homo sapiens	tRNA + 5'-oligoribonucleotide	-	?

Synonyms

Synonyms	Comment	Organism
ribonuclease P	-	Chlorobium limicola
ribonuclease P	-	Chlamydia trachomatis
ribonuclease P	-	Bacillus subtilis
ribonuclease P	-	Escherichia coli
ribonuclease P	-	Homo sapiens
ribonuclease P	-	Saccharomyces cerevisiae
ribonuclease P	-	Methanothermobacter thermautotrophicus
ribonuclease P	-	Giardia intestinalis
ribonuclease P	-	Cupriavidus necator
ribonuclease P	-	Methanocaldococcus jannaschii
ribonuclease P	-	Mycoplasmopsis fermentans
ribonuclease P	-	Pyrobaculum aerophilum
ribonuclease P	-	Thermomicrobium roseum
ribonuclease P	-	Mycoplasma hyopneumoniae
ribonuclease P	-	Synechococcus elongatus PCC 6301
ribonuclease P	-	Porphyra purpurea
ribonuclease P	-	Reclinomonas americana
RNase P	-	Chlorobium limicola
RNase P	-	Chlamydia trachomatis
RNase P	-	Bacillus subtilis
RNase P	-	Escherichia coli
RNase P	-	Homo sapiens
RNase P	-	Saccharomyces cerevisiae
RNase P	-	Methanothermobacter thermautotrophicus
RNase P	-	Giardia intestinalis
RNase P	-	Cupriavidus necator
RNase P	-	Methanocaldococcus jannaschii
RNase P	-	Mycoplasmopsis fermentans
RNase P	-	Pyrobaculum aerophilum
RNase P	-	Thermomicrobium roseum
RNase P	-	Mycoplasma hyopneumoniae
RNase P	-	Synechococcus elongatus PCC 6301
RNase P	-	Porphyra purpurea
RNase P	-	Reclinomonas americana

General Information

General Information	Comment	Organism
physiological function	mitochondrial RNase P RNA is primitive and recognizably similar to those of alpha-proteobacteria, the ancestors of mitochondria	Reclinomonas americana
physiological function	plastid RNase P RNA in the non-green alga is similar to those of their cyanobacterial ancestry	Porphyra purpurea
physiological function	the nuclear holoenzyme is comprised of protein subunits and RNase P RNA. In mitochondria, the usual RNA-containing RNase P is replaced by an enzyme composed of three proteins that are unrelated to RNase P enzymes in other systems (Rube Goldberg triad of unrelated proteins), but nevertheless are together responsible for the cleavage of pre-tRNA precursors	Homo sapiens
physiological function	the organism has distinct RNase P enzymes in the nucleus and mitochondria. The RNase P RNA from the mitochondrion is an example of a highly-derived (degenerate) mitochondrial RNase P RNA	Saccharomyces cerevisiae
physiological function	the RNase P holoenzyme is composed of a single RNA (type A1 RNase P RNA) and a single small protein subunit. Bacterial RNase P RNAs are comprised of two independently evolving domains, separated by P7. The RNA upstream and downstream of P7 contains all of the essential catalytic sequences and structures (C-domain). Changes in the RNA bound at each end by the two strands of P7 (the loop of P7) alter substrate specificity (S-domain). The RNA subunit is associated with a single, small conservative protein, encoded by the rnpA gene, which has an unusual left-handed betaalphabeta crossover connection and a large central cleft	Escherichia coli
physiological function	the RNase P holoenzyme is composed of a single RNA (type A2 RNase P RNA, lacks P13 and P14) and a single small protein subunit. Bacterial RNase P RNAs are comprised of two independently evolving domains, separated by P7. The RNA upstream and downstream of P7 contains all of the essential catalytic sequences and structures (C-domain). Changes in the RNA bound at each end by the two strands of P7 (the loop of P7) alter substrate specificity (S-domain). The RNA subunit is associated with a single, small conservative protein, encoded by the rnpA gene, which has an unusual left-handed betaalphabeta crossover connection and a large central cleft	Cupriavidus necator
physiological function	the RNase P holoenzyme is composed of a single RNA (type A3 RNase P RNA, with an altered L15 internal loop, in which the substrate 3'-NCCA tail is recognized) and a single small protein subunit. Bacterial RNase P RNAs are comprised of two independently evolving domains, separated by P7. The RNA upstream and downstream of P7 contains all of the essential catalytic sequences and structures (C-domain). Changes in the RNA bound at each end by the two strands of P7 (the loop of P7) alter substrate specificity (S-domain). The RNA subunit is associated with a single, small conservative protein, encoded by the rnpA gene, which has an unusual left-handed betaalphabeta crossover connection and a large central cleft	Chlamydia trachomatis
physiological function	the RNase P holoenzyme is composed of a single RNA (type A4 RNase P RNA, with an altered L15) and a single small protein subunit. Bacterial RNase P RNAs are comprised of two independently evolving domains, separated by P7. The RNA upstream and downstream of P7 contains all of the essential catalytic sequences and structures (C-domain). Changes in the RNA bound at each end by the two strands of P7 (the loop of P7) alter substrate specificity (S-domain). The RNA subunit is associated with a single, small conservative protein, encoded by the rnpA gene, which has an unusual left-handed betaalphabeta crossover connection and a large central cleft	Synechococcus elongatus PCC 6301
physiological function	the RNase P holoenzyme is composed of a single RNA (type A5 RNase P RNA, lacks P18) and a single small protein subunit. Bacterial RNase P RNAs are comprised of two independently evolving domains, separated by P7. The RNA upstream and downstream of P7 contains all of the essential catalytic sequences and structures (C-domain). Changes in the RNA bound at each end by the two strands of P7 (the loop of P7) alter substrate specificity (S-domain). The RNA subunit is associated with a single, small conservative protein, encoded by the rnpA gene, which has an unusual left-handed betaalphabeta crossover connection and a large central cleft	Chlorobium limicola
physiological function	the RNase P holoenzyme is composed of a single RNA (type B1 RNase P RNA) and a single small protein subunit. Bacterial RNase P RNAs are comprised of two independently evolving domains, separated by P7. The RNA upstream and downstream of P7 contains all of the essential catalytic sequences and structures (C-domain). Changes in the RNA bound at each end by the two strands of P7 (the loop of P7) alter substrate specificity (S-domain). The RNA subunit is associated with a single, small conservative protein, encoded by the rnpA gene, which has an unusual left-handed betaalphabeta crossover connection and a large central cleft	Bacillus subtilis
physiological function	the RNase P holoenzyme is composed of a single RNA (type B2 RNase P RNA, lacks P10.1) and a single small protein subunit. Bacterial RNase P RNAs are comprised of two independently evolving domains, separated by P7. The RNA upstream and downstream of P7 contains all of the essential catalytic sequences and structures (C-domain). Changes in the RNA bound at each end by the two strands of P7 (the loop of P7) alter substrate specificity (S-domain). The RNA subunit is associated with a single, small conservative protein, encoded by the rnpA gene, which has an unusual left-handed betaalphabeta crossover connection and a large central cleft	Mycoplasma hyopneumoniae
physiological function	the RNase P holoenzyme is composed of a single RNA (type B3 RNase P RNA, lacks P12) and a single small protein subunit. Bacterial RNase P RNAs are comprised of two independently evolving domains, separated by P7. The RNA upstream and downstream of P7 contains all of the essential catalytic sequences and structures (C-domain). Changes in the RNA bound at each end by the two strands of P7 (the loop of P7) alter substrate specificity (S-domain). The RNA subunit is associated with a single, small conservative protein, encoded by the rnpA gene, which has an unusual left-handed betaalphabeta crossover connection and a large central cleft	Mycoplasmopsis fermentans
physiological function	the RNase P holoenzyme is composed of a single RNA (type C RNase P RNA) and a single small protein subunit. Bacterial RNase P RNAs are comprised of two independently evolving domains, separated by P7. The RNA upstream and downstream of P7 contains all of the essential catalytic sequences and structures (C-domain). Changes in the RNA bound at each end by the two strands of P7 (the loop of P7) alter substrate specificity (S-domain). The RNA subunit is associated with a single, small conservative protein, encoded by the rnpA gene, which has an unusual left-handed betaalphabeta crossover connection and a large central cleft	Thermomicrobium roseum
physiological function	the RNase P holoenzyme is composed of a single RNA molecule (type A RNase P RNA) and several protein subunits	Methanothermobacter thermautotrophicus
physiological function	the RNase P holoenzyme is composed of a single RNA molecule (type M RNase P RNA, lacking P6, P8, P16 and P17) and several protein subunits	Methanocaldococcus jannaschii
physiological function	the RNase P holoenzyme is composed of a single RNA molecule (type T RNase P RNA, lacking the S-domain) and several protein subunits	Pyrobaculum aerophilum