Literature summary for 3.1.26.5 extracted from

Liu, J.; Shao, L.; Trang, P.; Yang, Z.; Reeves, M.; Sun, X.; Vu, G.P.; Wang, Y.; Li, H.; Zheng, C.; Lu, S.; Liu, F.
Inhibition of herpes simplex virus 1 gene expression and replication by RNase P-associated external guide sequences (2016), Sci. Rep., 6, 27068 .

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Application

Application	Comment	Organism
medicine	construction of external guide sequences (EGSs) from a variant to target the mRNA encoding herpes simplex virus 1 (HSV-1) major transcription regulator ICP4, which is essential for the expression of viral early and late genes and viral growth. The EGS variant induces human RNase P cleavage of ICP4 mRNA sequence 60times better than the EGS generated from a natural pre-tRNA. A decrease of about 97% and 75% in the level of ICP4 gene expression and an inhibition of about 7,000- and 500-fold in viral growth are observed in HSV infected cells expressing the variant and the pre-tRNA-derived EGS, respectively. The study shows that engineered external guide sequences (EGSs) can inhibit HSV-1 gene expression and viral growth. The results demonstrate the potential for engineered EGS RNAs to be developed and used as anti-HSV therapeutics	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q99575 AND O95707 AND Q969H6 AND O75817 AND O95059 AND Q9H633 AND Q9BUL9 AND P78346 AND P78345 AND O75818	human RNase P consists of a catalytic RNA moiety and about 10 protein subunits; POP1 (Q99575), POP4 (O95707), POP5 (Q969H6), POP7 (O75817), RPP14 (O95059), RPP21 (Q9H633), RPP25 (Q9BUL9), RPP30 (P78346), RPP38 (P78345) and RPP40 (O75818)	-

Synonyms

Synonyms	Comment	Organism
RNase P	-	Homo sapiens

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Release 2023.1 (January 2023)