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Literature summary for 3.1.3.1 extracted from
- Histochemical localization of alkaline phosphatase activity in decalcified bone and cartilage (2002), J. Histochem. Cytochem., 50, 333-340.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | bound | Homo sapiens | 16020 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | enzyme is important in bone formation and mineralization | ? | - |
? |  |
| additional information | Homo sapiens | enzyme is impportant in bone formation and mineralization | ? | - |
? | |
| additional information | Rattus norvegicus | enzyme is impportant in bone formation and mineralization | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
4 isozyme types: 1. nonspecific liver/bone/kidney, which is also present in osteoblast and neutrophilic granulocytes, 2. intestinal, 3. placental, 4. germ-cell | - |
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| a phosphate monoester + H2O = an alcohol + phosphate | Wide specificity. Also catalyses transphosphorylations. Some enzymes hydrolyse diphosphate | Mus musculus | |
| a phosphate monoester + H2O = an alcohol + phosphate | Wide specificity. Also catalyses transphosphorylations. Some enzymes hydrolyse diphosphate | Homo sapiens | |
| a phosphate monoester + H2O = an alcohol + phosphate | Wide specificity. Also catalyses transphosphorylations. Some enzymes hydrolyse diphosphate | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| bone | - |
Mus musculus | - |
| bone | - |
Homo sapiens | - |
| bone | - |
Rattus norvegicus | - |
| cartilage | matrix, articular, of proximal tibiae, highest activity in the hypertrophic zone | Mus musculus | - |
| cartilage | matrix, articular, of proximal tibiae, highest activity in the hypertrophic zone | Rattus norvegicus | - |
| chondrocyte | no activity in resting chondrocytes and the matrix of reserve zone | Rattus norvegicus | - |
| embryo | - |
Mus musculus | - |
| germ cell | - |
Homo sapiens | - |
| growth plate | - |
Mus musculus | - |
| growth plate | - |
Rattus norvegicus | - |
| intestine | - |
Homo sapiens | - |
| kidney | - |
Homo sapiens | - |
| liver | - |
Homo sapiens | - |
| additional information | 4 isozyme types: 1. nonspecific liver/bone/kidney, which is also present in osteoblast and neutrophilic granulocytes, 2. intestinal, 3. placental, 4. germ-cell | Homo sapiens | - |
| neutrophil | - |
Homo sapiens | - |
| osteoblast | - |
Mus musculus | - |
| osteoblast | - |
Homo sapiens | - |
| osteoblast | - |
Rattus norvegicus | - |
| placenta | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | enzyme is important in bone formation and mineralization | Mus musculus | ? | - |
? | |
| additional information | enzyme is impportant in bone formation and mineralization | Homo sapiens | ? | - |
? | |
| additional information | enzyme is impportant in bone formation and mineralization | Rattus norvegicus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| alkaline phosphatase | - |
Mus musculus |
| alkaline phosphatase | - |
Homo sapiens |
| alkaline phosphatase | - |
Rattus norvegicus |
| ALP | - |
Mus musculus |
| ALP | - |
Homo sapiens |
| ALP | - |
Rattus norvegicus |
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