Literature summary for 3.1.3.1 extracted from

Chakrabartty, A.; Stinson, R.A.
Properties of membrane-bound and solubilized forms of alkaline phosphatase from human liver (1983), Biochim. Biophys. Acta, 839, 174-180.

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Inhibitors

Inhibitors	Comment	Organism	Structure
1-bromotetramisole	-	Homo sapiens
L-homoarginine	-	Homo sapiens
NADH	-	Homo sapiens
phenyl phosphonate	competitive	Homo sapiens
phosphate	-	Homo sapiens
vanadate	-	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.026	-	2-naphthyl phosphate	purified enzyme	Homo sapiens
0.078	-	2-naphthyl phosphate	membrane-bound enzyme enzyme	Homo sapiens
0.088	-	p-nitrophenyl phosphate	purified enzyme	Homo sapiens
0.12	-	diphosphate	purified enzyme	Homo sapiens
0.2	-	pyridoxal phosphate	purified enzyme	Homo sapiens
0.21	-	diphosphate	membrane-bound enzyme	Homo sapiens
0.37	-	pyridoxal phosphate	membrane-bound enzyme	Homo sapiens
0.38	-	phospho-L-Ser	purified enzyme	Homo sapiens
0.39	-	p-nitrophenyl phosphate	membrane-bound enzyme	Homo sapiens
0.39	-	phospho-DL-Thr	purified enzyme	Homo sapiens
0.4	-	phospho-DL-Tyr	purified enzyme	Homo sapiens
0.68	-	phospho-L-Ser	membrane-bound enzyme	Homo sapiens
0.72	-	phospho-DL-Tyr	membrane-bound enzyme	Homo sapiens
0.9	-	phospho-DL-Thr	membrane-bound enzyme	Homo sapiens
1.5	-	beta-Glycerophosphate	purified enzyme	Homo sapiens
3	-	beta-Glycerophosphate	membrane-bound enzyme	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	bound to	Homo sapiens	16020	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2-naphthyl phosphate + H2O	-	Homo sapiens	2-naphthol + phosphate	-	?
2-phosphoglycerate + H2O	-	Homo sapiens	glycerol + phosphate	-	?
beta-glycerophosphate + H2O	-	Homo sapiens	glycerol + phosphate	-	?
diphosphate + H2O	-	Homo sapiens	2 phosphate	-	?
phospho-DL-Thr + H2O	-	Homo sapiens	phosphate + Thr	-	?
phospho-DL-Tyr + H2O	-	Homo sapiens	phosphate + Tyr	-	?
phosphoserine + H2O	-	Homo sapiens	phosphate + Ser	-	?
pyridoxal 5'-phosphate + H2O	-	Homo sapiens	?	-	?

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Release 2023.1 (January 2023)