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Literature summary for 3.1.3.16 extracted from

  • Mihindukulasuriya, K.A.; Zhou, G.; Qin, J.; Tan, T.H.
    Protein phosphatase 4 interacts with and down-regulates insulin receptor substrate 4 following tumor necrosis factor-alpha stimulation (2004), J. Biol. Chem., 279, 46588-46594.
    View publication on PubMed
Search for more literature for 3.1.3.16

Cloned(Commentary)

Cloned (Comment) Organism
expression of FLAG-tagged PP4 in HEK-293T cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens PP4 is involved in TNFalpha signalling, PP4 down-regulates IRS-4 and mediates TNFalpha-induced IRS-4 degradation, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant FLAG-tagged PP4 from HEK-293T cells by anti-FLAG immunoaffinity chromatography, co-purifies with the insulin receptor substrate-4 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293T cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information PP4 is involved in TNFalpha signalling, PP4 down-regulates IRS-4 and mediates TNFalpha-induced IRS-4 degradation, overview Homo sapiens ?
-
 ?
additional information PP4 interacts with the TNFalpha-inducible insulin receptor substrate-4, IRS-4, the interaction is increased after TNFalpha-stimulation Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Pp4
-
 Homo sapiens
PPP4
-
 Homo sapiens
PPX
-
 Homo sapiens
protein phosphatase 4
-
 Homo sapiens