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Literature summary for 3.1.3.16 extracted from
- Characterization of the role of a trimeric protein phosphatase complex in recovery from cisplatin-induced versus noncrosslinking DNA damage (2008), FEBS J., 275, 4211-4221.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phosphorylated H2AX + H2O | Saccharomyces cerevisiae | the Pph3p complex is required for dephosphorylation of H2AX, Pph21p (PP2Ac ortholog) is not involved in H2AX dephosphorylation | H2AX + phosphate | - |
? |  |
| phosphorylated H2AX + H2O | Saccharomyces cerevisiae AY925 | the Pph3p complex is required for dephosphorylation of H2AX, Pph21p (PP2Ac ortholog) is not involved in H2AX dephosphorylation | H2AX + phosphate | - |
? | |
| Rad53p + H2O | Saccharomyces cerevisiae | a complex of Pph3p and Psy2p may dephosphorylate Rad53p after it has been activated and phosphorylated in response to methylmethanesulfonate, but a cisplatin-induced activation and phosphorylation of Rad53p may require a complex of Pph3, Psy4p and Psy2p for dephosphorylation | ? | - |
? | |
| Rad53p + H2O | Saccharomyces cerevisiae AY925 | a complex of Pph3p and Psy2p may dephosphorylate Rad53p after it has been activated and phosphorylated in response to methylmethanesulfonate, but a cisplatin-induced activation and phosphorylation of Rad53p may require a complex of Pph3, Psy4p and Psy2p for dephosphorylation | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
- |
- |
| Saccharomyces cerevisiae AY925 | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phosphorylated H2AX + H2O | the Pph3p complex is required for dephosphorylation of H2AX, Pph21p (PP2Ac ortholog) is not involved in H2AX dephosphorylation | Saccharomyces cerevisiae | H2AX + phosphate | - |
? | |
| phosphorylated H2AX + H2O | the Pph3p complex is required for dephosphorylation of H2AX, Pph21p (PP2Ac ortholog) is not involved in H2AX dephosphorylation | Saccharomyces cerevisiae AY925 | H2AX + phosphate | - |
? | |
| Rad53p + H2O | a complex of Pph3p and Psy2p may dephosphorylate Rad53p after it has been activated and phosphorylated in response to methylmethanesulfonate, but a cisplatin-induced activation and phosphorylation of Rad53p may require a complex of Pph3, Psy4p and Psy2p for dephosphorylation | Saccharomyces cerevisiae | ? | - |
? | |
| Rad53p + H2O | a complex of Pph3p and Psy2p may dephosphorylate Rad53p after it has been activated and phosphorylated in response to methylmethanesulfonate, but a cisplatin-induced activation and phosphorylation of Rad53p may require a complex of Pph3, Psy4p and Psy2p for dephosphorylation | Saccharomyces cerevisiae AY925 | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| trimer | - |
Saccharomyces cerevisiae |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Pph21p | a PP2Ac ortholog | Saccharomyces cerevisiae |
| Pph3p | - |
Saccharomyces cerevisiae |
| protein serine/threonine phosphatase 3p | - |
Saccharomyces cerevisiae |
| Psy2p | regulatory subunit of Pph3p | Saccharomyces cerevisiae |
| Psy4p | regulatory subunit of Pph3p | Saccharomyces cerevisiae |
| Ydr075w | - |
Saccharomyces cerevisiae |
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