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Literature summary for 3.1.3.16 extracted from

  • Kim, S.I.; Kwak, J.H.; Wang, L.; Choi, M.E.
    Protein phosphatase 2A is a negative regulator of transforming growth factor-beta1-induced TAK1 activation in mesangial cells (2008), J. Biol. Chem., 283, 10753-10763.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information association of PP2A with transforming growth factor-beta-activated kinase 1 is enhanced by transforming growth factor-beta 1 stimulation Mus musculus

Protein Variants

Protein Variants Comment Organism
H118N phosphatase-deficient mutant of PP2AC Mus musculus
L309Q nonphosphatase-deficient mutant of PP2AC Mus musculus
Y307F nonphosphatase-deficient mutant of PP2AC Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
okadaic acid
-
Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
36000
-
1 * 65000 + 1 * 36000 + 1 * ?, the heterotrimer consists of a 36000 Da catalytic C subunit, a 65000 Da structural A subunit, and a regulatory B subunit PP2AB Mus musculus
65000
-
1 * 65000 + 1 * 36000 + 1 * ?, the heterotrimer consists of a 36000 Da catalytic C subunit, a 65000 Da structural A subunit, and a regulatory B subunit PP2AB Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus the expression of wild type PP2A catalytic subunit suppresses the MAPK kinase 3 phosphorylation ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
carboxymethylation PP2AC undergoes at least three different posttranslational modifications: phosphorylation of Tyr-307, carboxymethylation of Leu-309, and phosphorylation of unidentified threonine residues Mus musculus
phosphoprotein PP2AC undergoes at least three different posttranslational modifications: phosphorylation of Tyr-307, carboxymethylation of Leu-309, and phosphorylation of unidentified threonine residues Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
mesangial cell
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the expression of wild type PP2A catalytic subunit suppresses the MAPK kinase 3 phosphorylation Mus musculus ?
-
?
phosphorylated TAK1-binding protein 1 + H2O
-
Mus musculus TAK1-binding protein 1 + phosphate
-
?
phosphorylated transforming growth factor-beta-activated kinase 1 + H2O Thr187 in transforming growth factor-beta-activated kinase 1 is a major dephosphorylation target of PP2A, PP2A plays a pivotal role as a negative regulator of transforming growth factor-beta-activated kinase 1 activation in response to transforming growth factor-beta 1 Mus musculus transforming growth factor-beta-activated kinase 1 + phosphate
-
?

Subunits

Subunits Comment Organism
heterotrimer 1 * 65000 + 1 * 36000 + 1 * ?, the heterotrimer consists of a 36000 Da catalytic C subunit, a 65000 Da structural A subunit, and a regulatory B subunit PP2AB Mus musculus

Synonyms

Synonyms Comment Organism
PP2A
-
Mus musculus
PP2Ac catalytic subunit of PP2A Mus musculus
protein phosphatase 2A
-
Mus musculus