Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | association of PP2A with transforming growth factor-beta-activated kinase 1 is enhanced by transforming growth factor-beta 1 stimulation | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
H118N | phosphatase-deficient mutant of PP2AC | Mus musculus |
L309Q | nonphosphatase-deficient mutant of PP2AC | Mus musculus |
Y307F | nonphosphatase-deficient mutant of PP2AC | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
okadaic acid | - |
Mus musculus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
36000 | - |
1 * 65000 + 1 * 36000 + 1 * ?, the heterotrimer consists of a 36000 Da catalytic C subunit, a 65000 Da structural A subunit, and a regulatory B subunit PP2AB | Mus musculus |
65000 | - |
1 * 65000 + 1 * 36000 + 1 * ?, the heterotrimer consists of a 36000 Da catalytic C subunit, a 65000 Da structural A subunit, and a regulatory B subunit PP2AB | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | the expression of wild type PP2A catalytic subunit suppresses the MAPK kinase 3 phosphorylation | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
carboxymethylation | PP2AC undergoes at least three different posttranslational modifications: phosphorylation of Tyr-307, carboxymethylation of Leu-309, and phosphorylation of unidentified threonine residues | Mus musculus |
phosphoprotein | PP2AC undergoes at least three different posttranslational modifications: phosphorylation of Tyr-307, carboxymethylation of Leu-309, and phosphorylation of unidentified threonine residues | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
mesangial cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the expression of wild type PP2A catalytic subunit suppresses the MAPK kinase 3 phosphorylation | Mus musculus | ? | - |
? | |
phosphorylated TAK1-binding protein 1 + H2O | - |
Mus musculus | TAK1-binding protein 1 + phosphate | - |
? | |
phosphorylated transforming growth factor-beta-activated kinase 1 + H2O | Thr187 in transforming growth factor-beta-activated kinase 1 is a major dephosphorylation target of PP2A, PP2A plays a pivotal role as a negative regulator of transforming growth factor-beta-activated kinase 1 activation in response to transforming growth factor-beta 1 | Mus musculus | transforming growth factor-beta-activated kinase 1 + phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
heterotrimer | 1 * 65000 + 1 * 36000 + 1 * ?, the heterotrimer consists of a 36000 Da catalytic C subunit, a 65000 Da structural A subunit, and a regulatory B subunit PP2AB | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
PP2A | - |
Mus musculus |
PP2Ac | catalytic subunit of PP2A | Mus musculus |
protein phosphatase 2A | - |
Mus musculus |