Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Calmodulin | calcineurin is dependent on Ca2+/calmodulin | Gallus gallus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
A23187 | reduces the Ca2+ level and thereby inhibits Ca2+-dependent calcineurin | Gallus gallus | |
cyclosporin A | in vivo inhibition in cell culture, 40% inhibition at 0.002 mM in vitro | Gallus gallus | |
EGTA | reduces the Ca2+ level and thereby inhibits Ca2+-dependent calcineurin | Gallus gallus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | calcineurin is dependent on Ca2+/calmodulin | Gallus gallus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Gallus gallus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cell culture | - |
Gallus gallus | - |
chondrogenic cell | from distal parts of the limb buds of 4-day-old Ross hybrid chicken embryos | Gallus gallus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphorylated protein phosphatase inhibitor-1 + H2O | - |
Gallus gallus | protein phosphatase inhibitor-1 + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Ca-calmodulin-dependent protein phosphatase | - |
Gallus gallus |
calcineurin | - |
Gallus gallus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Gallus gallus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
assay at | Gallus gallus |
General Information | Comment | Organism |
---|---|---|
physiological function | calcineurin is one of the target molecules regulated by the changes of intracellular Ca2+ level, it has a regulatory role in Ca2+ cytosolic concentration and signaling in chondrogenic cells, Ca2+ plays an important role in chondrogenesis, cartilage formation and cartilage differentiation, overview | Gallus gallus |