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Literature summary for 3.1.3.16 extracted from

  • Matta, C.; Fodor, J.; Szijgyarto, Z.; Juhasz, T.; Gergely, P.; Csernoch, L.; Zakany, R.
    Cytosolic free Ca2+ concentration exhibits a characteristic temporal pattern during in vitro cartilage differentiation: a possible regulatory role of calcineurin in Ca-signalling of chondrogenic cells (2008), Cell Calcium, 44, 310-323.
    View publication on PubMed
Search for more literature for 3.1.3.16

Activating Compound

Activating Compound Comment Organism Structure
Calmodulin calcineurin is dependent on Ca2+/calmodulin Gallus gallus

Inhibitors

Inhibitors Comment Organism Structure
A23187 reduces the Ca2+ level and thereby inhibits Ca2+-dependent calcineurin Gallus gallus
cyclosporin A in vivo inhibition in cell culture, 40% inhibition at 0.002 mM in vitro Gallus gallus
EGTA reduces the Ca2+ level and thereby inhibits Ca2+-dependent calcineurin Gallus gallus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ calcineurin is dependent on Ca2+/calmodulin Gallus gallus

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cell culture
-
 Gallus gallus
-
chondrogenic cell from distal parts of the limb buds of 4-day-old Ross hybrid chicken embryos Gallus gallus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphorylated protein phosphatase inhibitor-1 + H2O
-
 Gallus gallus protein phosphatase inhibitor-1 + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
Ca-calmodulin-dependent protein phosphatase
-
 Gallus gallus
calcineurin
-
 Gallus gallus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Gallus gallus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 assay at Gallus gallus

General Information

General Information Comment Organism
physiological function calcineurin is one of the target molecules regulated by the changes of intracellular Ca2+ level, it has a regulatory role in Ca2+ cytosolic concentration and signaling in chondrogenic cells, Ca2+ plays an important role in chondrogenesis, cartilage formation and cartilage differentiation, overview Gallus gallus