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Literature summary for 3.1.3.16 extracted from

  • Kilili, G.K.; Kyriakis, J.M.
    Mammalian Ste20-like kinase (Mst2) indirectly supports Raf-1/ERK pathway activity via maintenance of protein phosphatase-2A catalytic subunit levels and consequent suppression of inhibitory Raf-1 phosphorylation (2010), J. Biol. Chem., 285, 15076-15087.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.16

Inhibitors

Inhibitors Comment Organism Structure
additional information knockout of Ste20-like kinase, Mst2, reduces the expression of the catalytic subunit of PP2A, RNAi silencing of Mst2 triggers a striking proteasome-dependent decrease in the levels of the catalytic subunit of PP2A. Treatment with the specific proteasome inhibitor lactacystin completely reverses the loss of HEI-193 cell PP2A-C incurred upon Mst2 RNAi. Mst2-dependent stabilization of PP2A-C is a posttranslational process likely involving a reduction in proteasome-dependent PP2A-C degradation Homo sapiens
additional information knockout of Ste20-like kinase, Mst2, reduces the expression of the catalytic subunit of PP2A, RNAi silencing of Mst2 triggers a striking proteasome-dependent decrease in the levels of the catalytic subunit of PP2A. Mst2-dependent stabilization of PP2A-C is a posttranslational process likely involving a reduction in proteasome-dependent PP2A-C degradation Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphorylated Raf-1 kinase + H2O Mus musculus phosphatase 2A dephosphorylates Raf-1 Ser259 in response to mitogens Raf 1 kinase + phosphate
-
 ?
phosphorylated Raf-1 kinase + H2O Homo sapiens phosphatase 2A dephosphorylates Raf-1 Ser259 in response to mitogens Raf 1 kinase + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEI-193 cell
-
 Homo sapiens
-
NIH-3T3 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphorylated Raf-1 kinase + H2O phosphatase 2A dephosphorylates Raf-1 Ser259 in response to mitogens Mus musculus Raf 1 kinase + phosphate
-
 ?
phosphorylated Raf-1 kinase + H2O phosphatase 2A dephosphorylates Raf-1 Ser259 in response to mitogens Homo sapiens Raf 1 kinase + phosphate
-
 ?
phosphorylated Raf-1 kinase + H2O activation of Raf-1 by dephopshorylation at Ser259 Mus musculus Raf 1 kinase + phosphate
-
 ?
phosphorylated Raf-1 kinase + H2O activation of Raf-1 by dephopshorylation at Ser259 Homo sapiens Raf 1 kinase + phosphate
-
 ?

Subunits

Subunits Comment Organism
trimer PP2A is a trimeric enzyme composed of a dimeric core consisting of a structural A subunit, a catalytic C subunit and a variable B subunit that confers targeting specificity Mus musculus
trimer PP2A is a trimeric enzyme composed of a dimeric core consisting of a structural A subunit, a catalytic C subunit and a variable B subunit that confers targeting specificity Homo sapiens

Synonyms

Synonyms Comment Organism
PP2A
-
 Mus musculus
PP2A
-
 Homo sapiens
protein phosphatase-2A
-
 Mus musculus
protein phosphatase-2A
-
 Homo sapiens
protein serine/threonine phosphatase 2A
-
 Mus musculus
protein serine/threonine phosphatase 2A
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism the enzyme is involved in the Raf-1/ERK pathway, overview Mus musculus
metabolism the enzyme is involved in the Raf-1/ERK pathway, overview Homo sapiens