Inhibitors | Comment | Organism | Structure |
---|---|---|---|
DSCR1 | a calcineurin inhibitor, encoded by gene Dscr1 on chromosome 21, is elevated in Down syndrome individuals. Increased dosage of Dyrk1A, appears to act in concert with Dscr1 to suppress tumor angiogenesis by further attenuating VEGF-calcineurin-NFAT signalling in endothelial cells, mechanism, overview. DSCR1-dependent inhibition of the VEGF-calcineurin-NFAT pathway in endothelial cells as a key component of the reduced cancer incidence in Down syndrome individuals | Homo sapiens | |
DSCR1 | a calcineurin inhibitor, encoded by gene Dscr1 on chromosome 21, is elevated in Down syndrome model mice | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
individuals with Down syndrome | - |
Mus musculus | - |
Down syndrome model Ts65Dn mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
endothelial cell | - |
Mus musculus | - |
endothelial cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
calcineurin | - |
Mus musculus |
calcineurin | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | DSCR1-dependent inhibition of the VEGF-calcineurin-NFAT pathway in endothelial cells as a key component of the reduced cancer incidence in Down syndrome individuals | Homo sapiens |
malfunction | modest elevation in expression afforded by a single extra transgenic copy of Dscr1 is sufficient to confer significant suppression of tumor growth in mice and that such resistance is a consequence of a deficit in tumor angiogenesis arising from suppression of the calcineurin pathway. Attenuation of calcineurin activity by DSCR1 together with another chromosome 21 gene DYRK1A, may be sufficient to dramatically diminish angiogenesis | Mus musculus |