Activating Compound | Comment | Organism | Structure |
---|---|---|---|
arachidonic acid | - |
Leishmania major |
Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21 cells | Leishmania major |
Protein Variants | Comment | Organism |
---|---|---|
E51A | the mutation on the TPR domain results in significantly increased activity | Leishmania major |
H276A | the mutation on the C-terminal abolishes enzyme activity | Leishmania major |
K72A | the mutation has no regulatory function in the catalytic activity of the enzyme | Leishmania major |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
okadaic acid | - |
Leishmania major |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphoprotein + H2O | Leishmania major | - |
protein + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Leishmania major | Q4QE27 | - |
- |
Purification (Comment) | Organism |
---|---|
GST-spin column chromatography | Leishmania major |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-nitrophenyl phosphate + H2O | - |
Leishmania major | 4-nitrophenol + phosphate | - |
? | |
phosphoprotein + H2O | - |
Leishmania major | protein + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PP5 | - |
Leishmania major |
serine/threonine protein phosphatase | - |
Leishmania major |