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Literature summary for 3.1.3.16 extracted from
- The serine/threonine phosphatase DhSIT4 modulates cell cycle, salt tolerance and cell wall integrity in halo tolerant yeast Debaryomyces hansenii (2017), Gene, 606, 1-9 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene DEHA2D13134g | Debaryomyces hansenii |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | deletion of DhSIT4 in Debaryomyces hansenii by gene disruption, the constructed knockout mutant Dhsit4DELTA shows sensitivity towards Li+, Na+ and cell wall damaging agents. The expression of DhSit4p rescues salt, caffeine and calcofluor white sensitivity of Dhmpk1DELTA strain. The mutant Dhsit4DELTA has very limited ability to utilize succinate, glycerol and ethanol in comparison to dextrose. In contrast, wild-type DBH93 can utilize all these respiratory substrates very well | Debaryomyces hansenii |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| [protein]-serine/threonine phosphate + H2O | Debaryomyces hansenii | - |
[protein]-serine/threonine + phosphate | - |
? |  |
| [protein]-serine/threonine phosphate + H2O | Debaryomyces hansenii JCM 1990 | - |
[protein]-serine/threonine + phosphate | - |
? | |
| [protein]-serine/threonine phosphate + H2O | Debaryomyces hansenii DBH93 | - |
[protein]-serine/threonine + phosphate | - |
? | |
| [protein]-serine/threonine phosphate + H2O | Debaryomyces hansenii ATCC 36239 | - |
[protein]-serine/threonine + phosphate | - |
? | |
| [protein]-serine/threonine phosphate + H2O | Debaryomyces hansenii NBRC 0083 | - |
[protein]-serine/threonine + phosphate | - |
? | |
| [protein]-serine/threonine phosphate + H2O | Debaryomyces hansenii CBS 767 | - |
[protein]-serine/threonine + phosphate | - |
? | |
| [protein]-serine/threonine phosphate + H2O | Debaryomyces hansenii IGC 2968 | - |
[protein]-serine/threonine + phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Debaryomyces hansenii | Q6BRX5 | - |
- |
| Debaryomyces hansenii ATCC 36239 | Q6BRX5 | - |
- |
| Debaryomyces hansenii CBS 767 | Q6BRX5 | - |
- |
| Debaryomyces hansenii DBH93 | Q6BRX5 | - |
- |
| Debaryomyces hansenii IGC 2968 | Q6BRX5 | - |
- |
| Debaryomyces hansenii JCM 1990 | Q6BRX5 | - |
- |
| Debaryomyces hansenii NBRC 0083 | Q6BRX5 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| [protein]-serine/threonine phosphate + H2O | - |
Debaryomyces hansenii | [protein]-serine/threonine + phosphate | - |
? | |
| [protein]-serine/threonine phosphate + H2O | - |
Debaryomyces hansenii JCM 1990 | [protein]-serine/threonine + phosphate | - |
? | |
| [protein]-serine/threonine phosphate + H2O | - |
Debaryomyces hansenii DBH93 | [protein]-serine/threonine + phosphate | - |
? | |
| [protein]-serine/threonine phosphate + H2O | - |
Debaryomyces hansenii ATCC 36239 | [protein]-serine/threonine + phosphate | - |
? | |
| [protein]-serine/threonine phosphate + H2O | - |
Debaryomyces hansenii NBRC 0083 | [protein]-serine/threonine + phosphate | - |
? | |
| [protein]-serine/threonine phosphate + H2O | - |
Debaryomyces hansenii CBS 767 | [protein]-serine/threonine + phosphate | - |
? | |
| [protein]-serine/threonine phosphate + H2O | - |
Debaryomyces hansenii IGC 2968 | [protein]-serine/threonine + phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DEHA2D13134g | - |
Debaryomyces hansenii |
| DhSIT4 | - |
Debaryomyces hansenii |
| phosphoprotein phosphatase | - |
Debaryomyces hansenii |
| PPP | - |
Debaryomyces hansenii |
| serine/threonine phosphatase | - |
Debaryomyces hansenii |
General Information
| General Information | Comment | Organism |
|---|---|---|
| evolution | enzyme DhSIT4 is a member of PPP6 class of serine threonine phosphatases from the halotolerant yeast Debaryomyces hansenii | Debaryomyces hansenii |
| malfunction | deletion of DhSIT4 in Debaryomyces hansenii is not lethal but the mutant exhibits reduced growth due to its effect on the cell cycle. The knockout mutant Dhsit4DELTA shows sensitivity towards Li+, Na+ and cell wall damaging agents. Growth pattern of Dhsit4DELTA knockout mutant in the presence of toxic cations and oxidative agents, overview. The expression of DhSit4p rescues salt, caffeine and calcofluor white sensitivity of Dhmpk1DELTA strain and thereby indicating a genetic interaction of this phosphatase with the cell wall integrity pathway in this species. Antagonistic roles of DhSit4p and DhPpz1p in maintaining the cell cycle and ion homeostasis in Debaryomyces hansenii. Mutant phenotype, overview | Debaryomyces hansenii |
| metabolism | role of DhSIT4 in cell wall integrity (CWI) signaling pathway in Debaryomyces hansenii | Debaryomyces hansenii |
| physiological function | the serine/threonine phosphatase DhSIT4 modulates cell cycle, salt tolerance and cell wall integrity in halotolerant yeast Debaryomyces hansenii, role of DhSIT4 in cell wall integrity (CWI) signaling pathway in Debaryomyces hansenii | Debaryomyces hansenii |
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