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Literature summary for 3.1.3.16 extracted from

  • Sharma, A.K.; Arora, D.; Singh, L.K.; Gangwal, A.; Sajid, A.; Molle, V.; Singh, Y.; Nandicoori, V.K.
    Serine/threonine protein phosphatase PstP of Mycobacterium tuberculosis is necessary for accurate cell division and survival of pathogen (2016), J. Biol. Chem., 291, 24215-24230 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.16

Protein Variants

Protein Variants Comment Organism
additional information creating a conditional gene replacement pstP mutant in Mycobacterium smegmatis, using the recombineering method, depletion of PstP in Mycobacterium smegmatis leads to cell death/poor cell survival, phenotype, overview Mycolicibacterium smegmatis
additional information overexpression and conditional gene replacement of pstP with depletion of PstP in Mycobacterium tuberculosis, phenotypes, overview Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[protein]-serine/threonine phosphate + H2O Mycolicibacterium smegmatis
-
 [protein]-serine/threonine + phosphate
-
 ?
[protein]-serine/threonine phosphate + H2O Mycobacterium tuberculosis
-
 [protein]-serine/threonine + phosphate
-
 ?
[protein]-serine/threonine phosphate + H2O Mycobacterium tuberculosis H37Rv
-
 [protein]-serine/threonine + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WHW5
-
-
Mycobacterium tuberculosis H37Rv P9WHW5
-
-
Mycolicibacterium smegmatis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[protein]-serine/threonine phosphate + H2O
-
 Mycolicibacterium smegmatis [protein]-serine/threonine + phosphate
-
 ?
[protein]-serine/threonine phosphate + H2O
-
 Mycobacterium tuberculosis [protein]-serine/threonine + phosphate
-
 ?
[protein]-serine/threonine phosphate + H2O
-
 Mycobacterium tuberculosis H37Rv [protein]-serine/threonine + phosphate
-
 ?

Subunits

Subunits Comment Organism
More domain structure overview Mycolicibacterium smegmatis
More domain structure overview Mycobacterium tuberculosis

Synonyms

Synonyms Comment Organism
PSTP
-
 Mycolicibacterium smegmatis
PSTP
-
 Mycobacterium tuberculosis
Rv0018c
-
 Mycobacterium tuberculosis
serine/threonine protein phosphatase
-
 Mycolicibacterium smegmatis
serine/threonine protein phosphatase
-
 Mycobacterium tuberculosis

General Information

General Information Comment Organism
malfunction overexpression of PstP leads to elongated cells and partially compromised survival. Depletion of PstP in Mycobacterium smegmatis leads to cell death Mycolicibacterium smegmatis
malfunction overexpression of PstP leads to elongated cells and partially compromised survival. Depletion of PstP is detrimental to cell survival, eventually leading to cell death. PstP depletion results in elongated multiseptate cells, suggesting a role for PstP in regulating cell division events. Depletion of PstP decreases the bacillary load even in an established infection. Marginally compromised survival in complementation experiments. All of the domains, including the extracellular domain, are necessary for complete rescue. Depletion of PstP from established infections causes pathogen clearance, indicating that the continued presence of PstP is necessary for pathogen survival Mycobacterium tuberculosis
physiological function serine/threonine protein phosphatase PstP of Mycobacterium tuberculosis is necessary for accurate cell division and survival of pathogen, role for PstP in regulating cell division events. The activity of PstP is essential for mycobacterial growth. All of the enzyme domains, including the extracellular domain, are necessary for enzyme activity in vivo. The catalytic activity of PstP is absolutely essential for the in vitro growth Mycolicibacterium smegmatis
physiological function serine/threonine protein phosphatase PstP of Mycobacterium tuberculosis is necessary for accurate cell division and survival of pathogen, role for PstP in regulating cell division events. The activity of PstP is essential for mycobacterial growth. All of the enzyme domains, including the extracellular domain, are necessary for enzyme activity in vivo. The catalytic activity of PstP is absolutely essential for the in vitro growth Mycobacterium tuberculosis