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Literature summary for 3.1.3.4 extracted from
- Characterization of phosphatidic acid phosphohydrolase in neutrophil subcellular fractions (1993), Biochim. Biophys. Acta, 1175, 219-224.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Triton X-100 | plasma membrane-associated activity is absolutely dependent on detergent | Homo sapiens |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| F- | - |
Homo sapiens | |
| NEM | inhibition of cytosolic and light membrane activity | Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.062 | - |
phosphatidic acid | - |
Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | 20% of the activity | Homo sapiens | 5829 | - |
| additional information | the majority of the activity is localized in particulate fraction | Homo sapiens | - |
- |
| plasma membrane | - |
Homo sapiens | 5886 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | moderate inhibition of cytosolic and particulate activity | Homo sapiens | |
| Mg2+ | markedly potentiates the cytosolic but not the particulate activity | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| neutrophil | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phosphatidic acid + H2O | - |
Homo sapiens | 1,2-diacyl-sn-glycerol + phosphate | - |
? | |
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