Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-oxo-4H-chromene-3-carbaldehyde | 50% inhibition at 0.073 mM, irreversible, selective for isoform PTP1B over other human protein tyrosine phosphatases | Homo sapiens | |
4-oxo-6,8-diphenyl-4H-chromene-3-carbaldehyde | 50% inhibition at 0.0033 mM, irreversible, selective for isoform PTP1B over other human protein tyrosine phosphatases, 50% inhibition of isoform LAR above 1 mM | Homo sapiens | |
4-oxo-6-(2-phenyl-1-benzothien-3-yl)-4H-chromene-3-carbaldehyde | 50% inhibition at 0.0062 mM, irreversible, selective for isoform PTP1B over other human protein tyrosine phosphatases | Homo sapiens | |
4-oxo-6-phenyl-4H-chromene-3-carbaldehyde | 50% inhibition at 0.014 mM, irreversible, selective for isoform PTP1B over other human protein tyrosine phosphatases | Homo sapiens | |
4-oxo-8-phenyl-4H-chromene-3-carbaldehyde | 50% inhibition at 0.016 mM, irreversible, selective for isoform PTP1B over other human protein tyrosine phosphatases | Homo sapiens | |
6,8-dibenzyl-4-oxo-4H-chromene-3-carbaldehyde | 50% inhibition at 0.013 mM, irreversible, selective for isoform PTP1B over other human protein tyrosine phosphatases | Homo sapiens | |
6-((2-benzyl-1-benzothien-3-yl)methyl)-4-oxo-4H-chromene-3-carbaldehyde | 50% inhibition at 0.0032 mM, irreversible, selective for isoform PTP1B over other human protein tyrosine phosphatases, 50% inhibition of isoform LAR above 1 mM | Homo sapiens | |
6-((E)-1,2-diphenylvinyl)-4-oxo-4H-chromene-3-carbaldehyde | 50% inhibition at 0.0097 mM, irreversible, selective for isoform PTP1B over other human protein tyrosine phosphatases | Homo sapiens | |
6-(1-benzothien-2-ylmethyl)-4-oxo-4H-chromene-3-carbaldehyde | 50% inhibition at 0.006 mM, irreversible, selective for isoform PTP1B over other human protein tyrosine phosphatases | Homo sapiens | |
6-(1-benzothien-3-yl)-4-oxo-4H-chromene-3-carbaldehyde | 50% inhibition at 0.0077 mM, irreversible, selective for isoform PTP1B over other human protein tyrosine phosphatases | Homo sapiens | |
6-(1-benzothien-3-ylmethyl)-4-oxo-4H-chromene-3-carbaldehyde | 50% inhibition at 0.06 mM, irreversible, selective for isoform PTP1B over other human protein tyrosine phosphatases | Homo sapiens | |
6-(10-bromo-9-anthryl)-4-oxo-4H-chromene-3-carbaldehyde | 50% inhibition at 0.0025 mM, irreversible, selective for isoform PTP1B over other human protein tyrosine phosphatases, 50% inhibition of isoform LAR at 0.57 mM | Homo sapiens | |
6-(4-((2-benzyl-1-benzothiophen-3-yl)methyl)phenyl)-4-oxo-4H-chromene-3-carbaldehyde | 50% inhibition at 0.0011 mM, irreversible, selective for isoform PTP1B over other human protein tyrosine phosphatases, 50% inhibition of isoform LAR above 1 mM | Homo sapiens | |
6-(4-((2-benzyl-1-benzothiophen-3-yl)methyl)phenyl)-4-oxo-8-phenyl-4H-chromene-3-carbaldehyde | 50% inhibition at 0.001 mM, irreversible, selective for isoform PTP1B over other human protein tyrosine phosphatases, 50% inhibition of isoform LAR at 0.52 mM | Homo sapiens | |
6-(9-anthryl)-4-oxo-4H-chromene-3-carbaldehyde | 50% inhibition at 0.0071 mM, irreversible, selective for isoform PTP1B over other human protein tyrosine phosphatases | Homo sapiens | |
6-benzyl-4-oxo-4H-chromene-3-carbaldehyde | 50% inhibition at 0.036 mM, irreversible, selective for isoform PTP1B over other human protein tyrosine phosphatases | Homo sapiens | |
6-biphenyl-4-yl-4-oxo-4H-chromene-3-carbaldehyde | 50% inhibition at 0.0043 mM, irreversible, selective for isoform PTP1B over other human protein tyrosine phosphatases | Homo sapiens | |
6-biphenyl-4-yl-4-oxo-8-phenyl-4H-chromene-3-carbaldehyde | 50% inhibition at 0.002 mM, irreversible, selective for isoform PTP1B over other human protein tyrosine phosphatases, 50% inhibition of isoform LAR above 1 mM | Homo sapiens | |
6-bromo-4-oxo-4H-chromene-3-carbaldehyde | 50% inhibition at 0.020 mM, irreversible, selective for isoform PTP1B over other human protein tyrosine phosphatases | Homo sapiens | |
6-dibenzo(b,d)thien-1-yl-4-oxo-4H-chromene-3-carbaldehyde | 50% inhibition at 0.0076 mM, irreversible, selective for isoform PTP1B over other human protein tyrosine phosphatases | Homo sapiens | |
6-dibenzo(b,d)thien-4-yl-4-oxo-4H-chromene-3-carbaldehyde | 50% inhibition at 0.011 mM, irreversible, selective for isoform PTP1B over other human protein tyrosine phosphatases | Homo sapiens | |
8-benzyl-4-oxo-4H-chromene-3-carbaldehyde | 50% inhibition at 0.018 mM, irreversible, selective for isoform PTP1B over other human protein tyrosine phosphatases | Homo sapiens | |
8-bromo-4-oxo-6-(2-phenyl-1-benzothien-3-yl)-4H-chromene-3-carbaldehyde | 50% inhibition at 0.0078 mM, irreversible, selective for isoform PTP1B over other human protein tyrosine phosphatases | Homo sapiens | |
8-bromo-6-(10-bromo-9-anthryl)-4-oxo-4H-chromene-3-carbaldehyde | 50% inhibition at 0.011 mM, irreversible, selective for isoform PTP1B over other human protein tyrosine phosphatases | Homo sapiens | |
8-bromo-6-(2-bromo-1-benzothien-3-yl)-4-oxo-4H-chromene-3-carbaldehyde | 50% inhibition at 0.0082 mM, irreversible, selective for isoform PTP1B over other human protein tyrosine phosphatases | Homo sapiens | |
8-bromo-6-dibenzo(b,d)thien-1-yl-4-oxo-4H-chromene-3-carbaldehyde | 50% inhibition at 0.010 mM, irreversible, selective for isoform PTP1B over other human protein tyrosine phosphatases | Homo sapiens | |
8-bromo-6-dibenzo(b,d)thien-4-yl-4-oxo-4H-chromene-3-carbaldehyde | 50% inhibition at 0.016 mM, irreversible, selective for isoform PTP1B over other human protein tyrosine phosphatases | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P18031 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
PTP1B | - |
Homo sapiens |